2. Gene
  3. GPD2 - glycerol-3-phosphate dehydrogenase 2 Gene

GPD2 - glycerol-3-phosphate dehydrogenase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：3-磷酸甘油脱氢酶 2

种属: Homo sapiens

同用名: GDH2; GPDM; mGDH; mGPDH

基因 ID: 2820 | 基因类型: protein coding

关于 GPD2

Cytogenetic location: 2q24.1 Genomic coordinates (GRCh38): 2:156,400,281-156,586,403 (from NCBI)

This gene has 13 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in colon (RPKM 11.8), brain (RPKM 10.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质定位于线粒体内膜，并以 FAD 作为辅因子催化 3- 磷酸甘油转化为磷酸二羟基丙酮。与 GDP1 一起，编码的蛋白质构成甘油磷酸穿梭机，它重新氧化糖酵解过程中形成的 NADH。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2010 年 1 月]

The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

GPD2 基因产物(2)

mRNA Protein Name
NM_000408.5 NP_000399.3 glycerol-3-phosphate dehydrogenase, mitochondrial precursor
NM_001083112.3 NP_001076581.2 glycerol-3-phosphate dehydrogenase, mitochondrial precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycerol-3-phosphate dehydrogenase (quinone) activity IDA
IDA: 通过直接分析推断
9070847 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPD2 蛋白结构

DAO

DAO: FAD dependent oxidoreductase (71 - 441)

EF-hand_7

EF-hand_7: EF-hand domain pair (628 - 688)

  • 0
  • 200
  • 400
  • 600
  • 727 a.a.
蛋白主名 其他名称

glycerol-3-phosphate dehydrogenase, mitochondrial

GPD-M

GPD2 抗体

目录号 产品名 应用 反应物种
HY-P83213 GPD2 Antibody (YA2958) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Methylmalonic Acidemia

Methylmalonic Aciduria

Mma

Acidemia, Methylmalonic

Isolated Methylmalonic Acidemia
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148685 KM04416 99.39% 否
HY-RS05635 GPD2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GPD2 VGNC VGNC:29531
Macaca mulatta GPD2 VGNC VGNC:97773
Felis catus GPD2 VGNC VGNC:67408
Rattus norvegicus GPD2 RGD RGD:2726
Canis familiaris GPD2 VGNC VGNC:41378
Mus musculus GPD2 MGD MGI:99778
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