2. Gene
  3. IFNL2 - interferon lambda 2 Gene

IFNL2 - interferon lambda 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：干扰素λ2

种属: Homo sapiens

同用名: IL28A; IFNL2a; IFNL3a; IL-28A

基因 ID: 282616 | 基因类型: protein coding

关于 IFNL2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,268,396-39,270,188 (from NCBI)

This gene has 1 transcript (splice variant), 136 orthologues and 2 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码与 I 型干扰素和 IL-10 家族远缘的细胞因子。该基因、白细胞介素 28B (IL28B) 和白细胞介素 29 (IL29) 是三个密切相关的细胞因子基因，它们在映射到 19q13 的染色体区域上形成细胞因子基因簇。病毒感染可诱导这三个基因编码的细胞因子的表达。所有三种细胞因子均已显示与异二聚体 II 类细胞因子受体相互作用，该受体由白细胞介素 10 受体 β (IL10RB) 和白细胞介素 28 受体 α (IL28RA) 组成。[RefSeq 提供，2008 年 7 月]

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

IFNL2 基因产物(1)

mRNA Protein Name
NM_172138.2 NP_742150.1 interferon lambda-2 precursor

IFNL2 蛋白结构

IL28A

IL28A: Interleukin-28A (37 - 197)

  • 0
  • 100
  • 200 a.a.
蛋白主名 其他名称

interferon lambda-2

IFN-lambda-2

重组 IFNL2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72553 IFN-lambda 2/IL-28A Protein, Human (HEK293, His) Q8IZJ0 (V26-V200) ≥95%
HY-P77005 IFN-lambda 2/IL-28A Protein, Human (P.pastoris, His) Q8IZJ0 (V26-V200) ≥95%
HY-P700119AF Animal-Free IFN-lambda 2/IL-28A Protein, Human (His) Q8IZJ0 (P27-V200) ≥95%

关联疾病

疾病名称 别名
Psoriasis 12

PSORS12

Psoriasis Susceptibility 12

Psoriasis 12, Susceptibility To
Immunodeficiency 28

IMD28

Ifngr2 Deficiency

Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive

Immunodeficiency 28, Mycobacteriosis

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency

Msmd Due To Complete Ifngammar2 Deficiency

Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency

Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency

Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency

Immunodeficiency, Type 28, Mycobacteriosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06592 IFNL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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