2. Gene
  3. IFNL3 - interferon lambda 3 Gene

IFNL3 - interferon lambda 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素λ3

种属: Homo sapiens

同用名: IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4

基因 ID: 282617 | 基因类型: protein coding

关于 IFNL3

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,243,455-39,245,250 (from NCBI)

This gene has 2 transcripts (splice variants), 136 orthologues, 2 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

该基因编码与 I 型干扰素和 IL-10 家族远缘的细胞因子。该基因、白细胞介素 28A (IL28A) 和白细胞介素 29 (IL29) 是三个密切相关的细胞因子基因，它们在映射到 19q13 的染色体区域上形成细胞因子基因簇。病毒感染可诱导这三个基因编码的细胞因子的表达。所有三种细胞因子均已显示与异二聚体 II 类细胞因子受体相互作用，该受体由白细胞介素 10 受体 β (IL10RB) 和白细胞介素 28 受体 α (IL28RA) 组成。[RefSeq 提供，2008 年 7 月]

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

IFNL3 基因产物(2)

mRNA Protein Name
NM_001346937.2 NP_001333866.1 interferon lambda-3 isoform 1
NM_172139.4 NP_742151.2 interferon lambda-3 isoform 2 precursor

IFNL3 蛋白结构

IL28A

IL28A: Interleukin-28A (33 - 193)

  • 0
  • 100
  • 196 a.a.
蛋白主名 其他名称

interferon lambda-3

cytokine Zcyto22

重组 IFNL3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73201 IFN-lambda 3/IL-28B Protein, Human (P.pastoris, His) Q8IZI9 (V18-V196) ≥95%
HY-P72552 IFN-lambda 3/IL-28B Protein, Human (HEK293, His) Q8IZI9 (V22-V196) ≥95%
HY-P700120AF Animal-Free IFN-lambda 3/IL-28B Protein, Human (His) Q8IZI9 (V22-V196) ≥95%

关联疾病

疾病名称 别名
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Cryoglobulinemia

Cryoimmunoglobulinaemia
Hepatitis D

Delta Hepatitis

Hepatitis Delta

Hdv

Hepatitis D Virus

Hepatitis D Infection
Viral Hepatitis

Animal Viral Hepatitis

Hepatitis, Viral, Animal

Human Viral Hepatitis

Viral Hepatitis With Hepatic Coma
Hepatitis E
Liver Cirrhosis

Cirrhosis

Cirrhosis Of Liver

CIRRH

Cryptogenic Cirrhosis

Cirrhosis, Cryptogenic

Cirrhosis Nos
Abacavir Allergy

Abc Allergy
Esophageal Varix

Esophageal Varices

Bleeding Esophageal Varices

Bleeding Oesophageal Varices

Esophageal Varices In Disease Classified Elsewhere, With Bleeding

Esophageal Varices With Bleeding

Esophageal Varices With Bleeding In Disease Ec

Esophageal Varices Without Bleeding

Esophageal Varices Without Mention Of Bleeding
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06593 IFNL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IFNL3 RGD RGD:1589046
Mus musculus IFNL3 NCBI NCBI:338374
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