2. Gene
  3. IFNL1 - interferon lambda 1 Gene

IFNL1 - interferon lambda 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素λ1

种属: Homo sapiens

同用名: IL29; IL-29

基因 ID: 282618 | 基因类型: protein coding

关于 IFNL1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,296,407-39,298,673 (from NCBI)

This gene has 1 transcript (splice variant), 140 orthologues and 2 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码与 I 型干扰素和 IL-10 家族远缘的细胞因子。该基因、白细胞介素 28A (IL28A) 和白细胞介素 28B (IL28B) 是三个密切相关的细胞因子基因，它们在映射到 19q13 的染色体区域上形成细胞因子基因簇。病毒感染可诱导这三个基因编码的细胞因子的表达。所有三种细胞因子均已显示与异二聚体 II 类细胞因子受体相互作用，该受体由白细胞介素 10 受体 β (IL10RB) 和白细胞介素 28 受体 α (IL28RA) 组成。[RefSeq 提供，2008 年 7 月]

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

IFNL1 基因产物(1)

mRNA Protein Name
NM_172140.2 NP_742152.1 interferon lambda-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-28 receptor binding IPI
IPI: 通过物理相互作用推断
12469119 GOA
enables signaling receptor binding IDA
IDA: 通过直接分析推断
12483210 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to virus IDA
IDA: 通过直接分析推断
12469119 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19346497 GOA
involved in negative regulation of T cell differentiation IDA
IDA: 通过直接分析推断
19346497 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15166220 GOA
involved in negative regulation of interleukin-13 production IDA
IDA: 通过直接分析推断
19346497 GOA
involved in negative regulation of interleukin-5 production IDA
IDA: 通过直接分析推断
19346497 GOA
involved in negative regulation of memory T cell differentiation IDA
IDA: 通过直接分析推断
19346497 GOA
involved in negative regulation of type 2 immune response IDA
IDA: 通过直接分析推断
19346497 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12483210 GOA
involved in positive regulation of MHC class I biosynthetic process IDA
IDA: 通过直接分析推断
12483210 GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
12483210 GOA
involved in positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
19346497 GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: 通过直接分析推断
15166220 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
12483210 GOA
part of interleukin-28 receptor complex IDA
IDA: 通过直接分析推断
12469119 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFNL1 蛋白结构

IL28A

IL28A: Interleukin-28A (29 - 187)

  • 0
  • 100
  • 200 a.a.
蛋白主名 其他名称

interferon lambda-1

IFN-lambda-1

重组 IFNL1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7026 IFN-lambda 1/IL-29 Protein, Human Q8IU54 (G20-T200) ≥95%
HY-P72551 IFN-lambda 1/IL-29 Protein, Human (181a.a, HEK293, His) Q8IU54 (G20-T200) ≥95%
HY-P73202 IFN-lambda 1/IL-29 Protein, Human (HEK293) Q8IU54 (G20-T200) ≥95%
HY-P700121AF Animal-Free IFN-lambda 1/IL-29 Protein, Human (His) Q8IU54 (P23-T200) ≥95%

关联疾病

疾病名称 别名
Psoriasis 12

PSORS12

Psoriasis Susceptibility 12

Psoriasis 12, Susceptibility To
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Inflammatory Bowel Disease 23

IBD23
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06591 IFNL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IFNL1 RGD RGD:6493686
Others IFNL1 NCBI
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