2. Gene
  3. SLC26A11 - solute carrier family 26 member 11 Gene

SLC26A11 - solute carrier family 26 member 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 26 成员 11

种属: Homo sapiens

基因 ID: 284129 | 基因类型: protein coding

关于 SLC26A11

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,220,427-80,253,500 (from NCBI)

This gene has 17 transcripts (splice variants), 213 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 8.3), spleen (RPKM 6.4) and 25 other tissues.

功能概要

该基因编码溶质连接载体 26 阴离子交换剂家族的成员。该蛋白质家族的成员对许多细胞功能至关重要，包括稳态和细胞内电解质平衡。编码的蛋白质是一种不依赖于钠的硫酸盐转运蛋白，对阴离子交换剂抑制剂 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid 敏感。交替剪接导致多个转录变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

SLC26A11 基因产物(4)

mRNA Protein Name
NM_001166347.2 NP_001159819.1 sodium-independent sulfate anion transporter
NM_001166348.2 NP_001159820.1 sodium-independent sulfate anion transporter
NM_001166349.2 NP_001159821.1 sodium-independent sulfate anion transporter
NM_173626.4 NP_775897.3 sodium-independent sulfate anion transporter
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monoatomic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
12626430 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in sulfate transmembrane transport IDA
IDA: 通过直接分析推断
12626430 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
12626430 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12626430 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
20957757 GOA
located in membrane IDA
IDA: 通过直接分析推断
12626430 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12626430 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC26A11 蛋白结构

(34 - 113)

Sulfate_transp

Sulfate_transp: Sulfate permease family (137 - 436)

STAS

STAS: STAS domain (472 - 575)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 606 a.a.
蛋白主名 其他名称

sodium-independent sulfate anion transporter

solute carrier family 26 (anion exchanger), member 11

关联疾病

疾病名称 别名
Sialolithiasis

Sialolith

Stone Of Salivary Gland Or Duct

Salivary Gland Calculi

Salivary Gland Stone

Calculus Of Salivary Gland Or Duct

Calculus Of Salivary Gland

Salivary Calculus

Salivary Gland Calculus

Salivary Stone

Salivary Duct Calculi

Sialodocholithiasis
Pendred Syndrome

Goiter-Deafness Syndrome

Deafness With Goiter

PDS

Thyroid Dyshormonogenesis 2b

Tdh2b

Autosomal Recessive Sensorineural Hearing Impairment And Goiter

Pendred'S Syndrome

Thyroid Hormonogenesis, Genetic Defect In, 2b

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b

Congenital Hypothyroidism Due To Dyshormonogenesis 2b

Genetic Defect In Thyroid Hormonogenesis 2b

Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter

Goiter-Hearing Loss Syndrome

Goitre-Deafness Syndrome

Goitre Deafness
Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13135 SLC26A11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC26A11 MGD MGI:2444589
Felis catus SLC26A11 VGNC VGNC:65282
Canis familiaris SLC26A11 VGNC VGNC:46321
Bos taurus SLC26A11 VGNC VGNC:34776
Macaca mulatta SLC26A11 VGNC VGNC:77482
Rattus norvegicus SLC26A11 RGD RGD:1306178
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