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  2. GPR34 - G protein-coupled receptor 34 Gene

GPR34 - G protein-coupled receptor 34 Gene

中文名称:G 蛋白偶联受体 34

种属: Homo sapiens

同用名: LYPSR1

基因 ID: 2857 | 基因类型: protein coding

关于 GPR34

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:41,688,973-41,697,275 (from NCBI)

This gene has 3 transcripts (splice variants), 230 orthologues and 6 paralogues. Broad expression in placenta (RPKM 8.9), fat (RPKM 7.8) and 21 other tissues.

功能概要

蛋白偶联受体 (GPCR) ,如 GPR34,是包含 7 个假定跨膜结构域 (TM) 的完整膜蛋白。这些蛋白质通过激活异源三聚体 G 蛋白将信号传递到细胞内部,进而激活各种效应蛋白,最终导致生理反应。[OMIM 提供,2006 年 4 月]

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]

GPR34 基因产物(2)

mRNA Protein Name
NM_001097579.2 NP_001091048.1 probable G-protein coupled receptor 34
NM_005300.4 NP_005291.1 probable G-protein coupled receptor 34

GPR34 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (71 - 327)

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  • 381 a.a.
蛋白主名 其他名称

probable G-protein coupled receptor 34

关联疾病

疾病名称 别名
Alzheimer Disease 14

AD14

Alzheimer'S Disease 14

Alzheimer Disease-14

Alzheimer'S Disease 14, Late Onset

Night Blindness

Nyctalopia

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GPR34 VGNC VGNC:73133
Rattus norvegicus GPR34 RGD RGD:1563681
Canis familiaris GPR34 VGNC VGNC:41431
Bos taurus GPR34 VGNC VGNC:29583
Felis catus GPR34 VGNC VGNC:82436
Mus musculus GPR34 MGD MGI:1346334