2. Gene
  3. GPR35 - G protein-coupled receptor 35 Gene

GPR35 - G protein-coupled receptor 35 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 35

种属: Homo sapiens

基因 ID: 2859 | 基因类型: protein coding

关于 GPR35

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:240,605,430-240,633,159 (from NCBI)

This gene has 5 transcripts (splice variants), 228 orthologues, 16 paralogues and is associated with 1 phenotype. Biased expression in duodenum (RPKM 17.7), small intestine (RPKM 16.7) and 7 other tissues.

功能概要

启用 CXC 趋化因子受体活性。参与多个过程，包括趋化因子介导的信号通路；电压门控钙通道活动的负调节；和细胞溶质钙离子浓度的正调节。是质膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables C-X-C Chemokine Receptor activity. Involved in several processes, including chemokine-mediated signaling pathway; negative regulation of voltage-gated Calcium Channel activity; and positive regulation of cytosolic calcium ion concentration. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR35 基因产物(4)

mRNA Protein Name
NM_001195381.3 NP_001182310.1 G-protein coupled receptor 35 isoform b
NM_001195382.3 NP_001182311.1 G-protein coupled receptor 35 isoform b
NM_005301.5 NP_005292.2 G-protein coupled receptor 35 isoform a
NM_001394730.1 NP_001381659.1 G-protein coupled receptor 35 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables C-X-C chemokine receptor activity IDA
IDA: 通过直接分析推断
29068046 GOA
enables C-X-C chemokine receptor activity IMP
IMP: 通过突变表型推断
25411203 GOA
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
16754668 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
16754668 GOA
involved in chemokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
25411203 GOA
involved in chemokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
25411203 GOA
involved in negative regulation of voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
17940199 GOA
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
25411203 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
16754668 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR35 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (38 - 276)

  • 0
  • 100
  • 200
  • 309 a.a.
蛋白主名 其他名称

G-protein coupled receptor 35

KYNA receptor

kynurenic acid receptor

关联疾病

疾病名称 别名
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly

SRTD10

Short-Rib Thoracic Dysplasia 10 Without Polydactyly

Short Rib-Polydactyly Syndrome
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Microphthalmia, Isolated 1

Isolated Microphthalmia 1

MCOP1

Mcop

Anophthalmia, Clinical, Isolated

Microphthalmos, Autosomal Recessive
Retinitis Pigmentosa 71

RP71

Retinitis Pigmentosa, Type 71
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-100806 Kynurenic acid Agonist 99.21% Phase 1
HY-107512 Kynurenic acid sodium Agonist 99.79% Phase 1
HY-100806R Kynurenic acid (Standard) Agonist / Phase 1
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W008613 Pamoic acid Agonist 98.15% 否
HY-B1816 Zaprinast Agonist 99.95% 否
HY-107537 CID 2745687 Agonist 98.07% 否
HY-107536 ML 145 97.04% 否
HY-100806S Kynurenic acid-d5 Agonist 98.35% 否
HY-W010907 Pamoic acid disodium Agonist ≥98.0% 否
HY-134801 CID1231538 99.74% 否
HY-101033 GPR35 agonist 1 99.22% 否
HY-149190 GPR35 agonist 5 Agonist 98.86% 否
HY-15705 GPR35 agonist 2 Agonist 98.84% 否
HY-W018158 DHICA Activator / 否
HY-107538 YE120 Agonist 99.80% 否
HY-107539 GPR35 agonist 4 Agonist ≥99.0% 否
HY-169304 Gpr35 modulator 3 Modulator / 否
HY-106481 Bufrolin Agonist / 否
HY-169302 GPR35 activator-1 Activator / 否
HY-101958 Tyrphostin 25 Agonist 99.00% 否
HY-131728 GPR35 agonist 3 Agonist 98.32% 否
HY-169301 Gpr35 modulator 1 Modulator / 否
HY-169303 Gpr35 modulator 2 Modulator / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GPR35 VGNC VGNC:73134
Canis familiaris GPR35 VGNC VGNC:110509
Mus musculus GPR35 MGD MGI:1929509
Bos taurus GPR35 VGNC VGNC:29584
Rattus norvegicus GPR35 RGD RGD:1309404
Felis catus GPR35 VGNC VGNC:67425
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