GPX5 - glutathione peroxidase 5 Gene

中文名称：谷胱甘肽过氧化物酶 5

种属: Homo sapiens

同用名: EGLP; GPx-5; GSHPx-5; HEL-S-75p

关于 GPX5

功能概要

该基因属于谷胱甘肽过氧化物酶家族。它在哺乳动物雄性生殖道的附睾中特异性表达，并受雄激素调节。与其他几种特征性谷胱甘肽过氧化物酶不同，这种酶不是硒蛋白，缺乏硒代半胱氨酸残基。因此，它不依赖于硒，并且已被提议在保护精子膜免受脂质过氧化的破坏作用和/或防止过早的顶体反应中发挥作用。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2016 年 10 月]

This gene belongs to the Glutathione Peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several Other characterized glutathione peroxidases, this Enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]