2. Gene
  3. PHPT1 - phosphohistidine phosphatase 1 Gene

PHPT1 - phosphohistidine phosphatase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸组氨酸磷酸酶 1

种属: Homo sapiens

同用名: PHP; PHP14; CGI-202; HSPC141; HEL-S-132P

基因 ID: 29085 | 基因类型: protein coding

关于 PHPT1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,849,409-136,851,024 (from NCBI)

This gene has 6 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in heart (RPKM 26.6), prostate (RPKM 24.5) and 25 other tissues.

功能概要

该基因编码的酶可催化蛋白质中组氨酸残基的可逆去磷酸化。它可能参与 G-β 和 ATP 柠檬酸裂解酶的去磷酸化，并通过去磷酸化和抑制 KCa3.1 通道负向调节 CD4 T 淋巴细胞。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 12 月]

This gene encodes an Enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP Citrate Lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

PHPT1 基因产物(4)

mRNA Protein Name
NM_001135861.3 NP_001129333.1 14 kDa phosphohistidine phosphatase isoform 2
NM_001287342.2 NP_001274271.1 14 kDa phosphohistidine phosphatase isoform 4
NM_001287343.2 NP_001274272.1 14 kDa phosphohistidine phosphatase isoform 5
NM_014172.6 NP_054891.2 14 kDa phosphohistidine phosphatase isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IDA
IDA: 通过直接分析推断
27924678 GOA
enables calcium channel inhibitor activity IDA
IDA: 通过直接分析推断
18796614 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
enables protein histidine phosphatase activity IDA
IDA: 通过直接分析推断
16219293 GOA
enables protein histidine phosphatase activity IMP
IMP: 通过突变表型推断
18796614 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
18796614 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
27924678 GOA
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
19344975 GOA
involved in lamellipodium organization IDA
IDA: 通过直接分析推断
27924678 GOA
involved in negative regulation of ATP citrate synthase activity IDA
IDA: 通过直接分析推断
18656514 GOA
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
18796614 GOA
involved in negative regulation of lyase activity IDA
IDA: 通过直接分析推断
20110805 GOA
involved in peptidyl-histidine dephosphorylation IDA
IDA: 通过直接分析推断
16219293 GOA
involved in positive regulation of cell motility IMP
IMP: 通过突变表型推断
19344975 GOA
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
20501872 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
20501872 GOA
located in leading edge of lamellipodium IDA
IDA: 通过直接分析推断
27924678 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PHPT1 蛋白结构

Ocnus

Ocnus: Janus/Ocnus family (Ocnus) (6 - 118)

  • 0
  • 100
  • 125 a.a.
蛋白主名 其他名称

14 kDa phosphohistidine phosphatase

epididymis secretory sperm binding protein Li 132P

PHPT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PHPT1 Q9NRX4 KCNN4 Homo sapiens O15554
Anti Tag CoIP
18796614
种属内
PHPT1 Q9NRX4 ATXN1 Homo sapiens P54253
Y2H
16713569
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PHPT1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71769 PHPT1 Protein, Human (P.pastoris, His) Q9NRX4-1 (M1-Y125) ≥95%
HY-P75975 PHPT1 Protein, Human (His) Q9NRX4-1 (A2-Y125) ≥95%

关联疾病

疾病名称 别名
Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome

Rh Disease

HDFNRH

Rh Fetomaternal Incompatibility

Rh-Null Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-156029 IA1-8H2 / 否
HY-RS10453 PHPT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PHPT1 RGD RGD:1311355
Canis familiaris PHPT1 VGNC VGNC:44509
Felis catus PHPT1 VGNC VGNC:64153
Mus musculus PHPT1 MGD MGI:1922704
Bos taurus PHPT1 VGNC VGNC:32846
Others PHPT1 NCBI
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