GRM6 - glutamate metabotropic receptor 6 Gene

中文名称：谷氨酸代谢型受体 6

种属: Homo sapiens

同用名: mGlu6; CSNB1B; GPRC1F; MGLUR6

基因 ID: 2916 | 基因类型: protein coding

关于 GRM6

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:178,978,327-178,995,320 (from NCBI)

This gene has 6 transcripts (splice variants), 250 orthologues, 7 paralogues and is associated with 4 phenotypes. Low expression observed in reference dataset.

功能概要

L-谷氨酸是中枢神经系统中主要的兴奋性神经递质，可激活离子型和代谢型谷氨酸受体。谷氨酸能神经传递涉及正常大脑功能的大多数方面，并且在许多神经病理学状况下可能受到干扰。代谢型谷氨酸受体是 G 蛋白偶联受体家族，根据序列同源性、推定的信号转导机制和药理学特性将其分为 3 组。 I 组包括 GRM1 和 GRM5，这些受体已显示可激活磷脂酶 C。II 组包括 GRM2 和 GRM3，而 III 组包括 GRM4、GRM6、GRM7 和 GRM8。 II 组和 III 组受体与环 AMP 级联的抑制有关，但它们的激动剂选择性不同。该基因的突变会导致 1B 型先天性静止性夜盲症。[RefSeq 提供，2018 年 5 月]

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Mutations in this gene result in congenital stationary night blindness type 1B. [provided by RefSeq, May 2018]

GRM6 基因产物(1)

mRNA	Protein	Name
NM_000843.4	NP_000834.2	metabotropic glutamate receptor 6 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables glutamate receptor activity	IMP IMP: 通过突变表型推断	23452348	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17405131	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	17405131	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled glutamate receptor signaling pathway	IMP IMP: 通过突变表型推断	23452348	GOA
involved in detection of light stimulus involved in visual perception	IMP IMP: 通过突变表型推断	17405131	GOA
involved in positive regulation of calcium ion import across plasma membrane	IMP IMP: 通过突变表型推断	23452348	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi membrane	IDA IDA: 通过直接分析推断	17405131	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	17405131	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	17405131	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRM6 蛋白结构

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
877 a.a.

蛋白主名

其他名称

metabotropic glutamate receptor 6

glutamate receptor, metabotropic 6

关联疾病

疾病名称

别名

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Night Blindness, Congenital Stationary, Type 1b

Congenital Stationary Night Blindness 1b	CSNB1B
Night Blindness, Congenital Stationary, Complete, Autosomal Recessive	Csnb, Complete, Autosomal Recessive
Night Blindness, Congenital Stationary , 1b, Autosomal Recessive	Autosomal Recessive Complete Congenital Stationary Night Blindness
Congenital Stationary Night Blindness 1b Autosomal Recessive	Night Blindness, Congenital Stationary, 1b
Complete Autosomal Recessive Csnb	Complete Congenital Stationary Night Blindness Autosomal Recessive
Blindness, Night, Stationary, Congenital, Type 1b

Night Blindness

Nyctalopia

Cone-Rod Dystrophy, X-Linked, 3

CORDX3	X-Linked Cone-Rod Dystrophy 3
Cone-Rod Dystrophy X-Linked 3	Cone-Rod Dystrophy, X-Linked 3
Dystrophy, Cone-Rod, X-Linked, Type 3

Strabismic Amblyopia

Suppression Amblyopia	Amblyopia, Suppression
Amblyopia

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Night Blindness, Congenital Stationary, Type 1a

Congenital Stationary Night Blindness 1a	CSNB1A
Hemeralopia-Myopia	Myopia-Night Blindness
Night Blindness, Congenital Stationary , 1a, X-Linked	Congenital Stationary Night Blindness With Myopia
Csnb, Complete, X-Linked	Night Blindness, Congenital Stationary, With Myopia
Nbm1	Complete Csnb X-Linked
Congenital Stationary Night Blindness 1a X-Linked	Nbmi
Night Blindness, Congenital Stationary, 1a	Complete X-Linked Csnb
Nyctalopia	Xlcsnb
X-Linked Congenital Stationary Night Blindness	Blindness, Night, Stationary, Congenital, Type 1a
Night Blindness	X-Linked Csnb
Night Blindness, Congenital Stationary, Type 2a

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Retinitis Pigmentosa 14

RP14	Retinitis Pigmentosa Juvenile Tulp1-Related
Retinitis Pigmentosa-14	Retinitis Pigmentosa, Type 14

Fundus Albipunctatus

Retinitis Punctata Albescens	Pigmentary Retinal Dystrophy
RPA	Albipunctate Retinal Dystrophy
Lauber'S Disease	FALBI
Fa

Familial Isolated Hypoparathyroidism

Fih

Refractive Error

Refractive Errors

Abnormal Threshold Of Rods

Abnormal Dark Adaptation Curve

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05834	GRM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05835	Grm6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05836	Grm6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	GRM6	VGNC	VGNC:73290
Canis familiaris	GRM6	VGNC	VGNC:41513
Bos taurus	GRM6	VGNC	VGNC:29661
Felis catus	GRM6	VGNC	VGNC:67480
Mus musculus	GRM6	MGD	MGI:1351343
Rattus norvegicus	GRM6	RGD	RGD:2747

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GRM6 - glutamate metabotropic receptor 6 Gene

关于 GRM6

功能概要

GRM6 基因产物(1)

GRM6 蛋白结构

关联疾病

直系同源

热门区域

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GRM6 - glutamate metabotropic receptor 6 Gene

关于 GRM6

功能概要

GRM6 基因产物(1)

GRM6 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z