2. Gene
  3. Ntrk3 - neurotrophic receptor tyrosine kinase 3 Gene

Ntrk3 - neurotrophic receptor tyrosine kinase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：神经营养 受体酪氨酸激酶 3

种属: Rattus norvegicus

同用名: trkC

基因 ID: 29613 | 基因类型: protein coding

关于 Ntrk3

Primary_assembly 1: 132,132,849-132,503,286 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 271 orthologues, 54 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 154.8), Adrenal (RPKM 34.) and 6 other tissues.

功能概要

该基因编码的蛋白可启动 GPI 相关肝配蛋白受体活性。参与多个过程，包括细胞对视黄酸的反应；神经元的产生；和突触组装的调节。位于细胞质和质膜中。在谷氨酸能突触中活跃。是突触后膜的组成部分。该基因的人类直系同源物与腺样囊性癌有关；结直肠癌；和胃癌。与人类 NTRK3（神经营养受体酪氨酸激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables GPI-linked Ephrin Receptor activity. Involved in several processes, including cellular response to retinoic acid; generation of neurons; and regulation of synapse assembly. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach Cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk3 基因产物(3)

mRNA Protein Name
NM_019248.2 NP_062121.1 NT-3 growth factor receptor isoform 3 precursor
NM_001270656.1 NP_001257585.1 NT-3 growth factor receptor isoform 1 precursor
NM_001270655.1 NP_001257584.1 NT-3 growth factor receptor isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GPI-linked ephrin receptor activity IDA
IDA: 通过直接分析推断
19036963 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17341134 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to retinoic acid IEP
IEP: 通过表达模式推断
10027563 RGD
involved in cochlea development IEP
IEP: 通过表达模式推断
10494076 RGD
involved in negative regulation of astrocyte differentiation IMP
IMP: 通过突变表型推断
12075995 RGD
involved in neuron fate specification IMP
IMP: 通过突变表型推断
15247919 RGD
involved in neuron migration IMP
IMP: 通过突变表型推断
12075995 RGD
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
8494647 RGD
involved in postsynaptic density assembly EXP
EXP: 通过实验结果推断
21262467 RGD
involved in postsynaptic density assembly IDA
IDA: 通过直接分析推断
21262467 RGD
involved in regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
12075995 RGD
involved in regulation of presynapse assembly IDA
IDA: 通过直接分析推断
21262467 RGD
involved in regulation of presynapse assembly IMP
IMP: 通过突变表型推断
21262467 RGD
involved in response to axon injury IEP
IEP: 通过表达模式推断
17532148 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
14557907 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
11743997 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
21262467 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21262467 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21262467 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
21262467 RGD
is active in postsynaptic membrane IMP
IMP: 通过突变表型推断
21262467 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ntrk3 蛋白结构

LRRNT

LRRNT: pfam01462 (30 - 50)

LRR_8

LRR_8: pfam13855 (102 - 159)

LRR_1

LRR_1: sd00031 (104 - 127)

LRR_1

LRR_1: sd00031 (128 - 150)

LRR_1

LRR_1: sd00031 (151 - 163)

TPKR_C2

TPKR_C2: pfam16920 (162 - 207)

ig

ig: pfam00047 (213 - 298)

Ig

Ig: cd00096 (226 - 230)

Ig

Ig: cd00096 (239 - 243)

Ig

Ig: cd00096 (265 - 269)

Ig

Ig: cd00096 (280 - 285)

Ig

Ig: cd00096 (293 - 296)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (303 - 395)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (304 - 310)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (312 - 315)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (318 - 326)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (329 - 336)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (339 - 342)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (347 - 353)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (357 - 365)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (373 - 381)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (384 - 392)

PTKc_TrkC

PTKc_TrkC: cd05094 (531 - 856)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 864 a.a.
蛋白主名 其他名称

NT-3 growth factor receptor

GP145-TrkC

neural receptor protein-tyrosine kinase (trkC)

neurotrophic tyrosine kinase, receptor, type 3

trk-C

trkC tyrosine kinase

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16749 Pexidartinib 99.64% 是
HY-16749A Pexidartinib hydrochloride 99.86% 是
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-131003 Taletrectinib Inhibitor 99.78% Phase 2
HY-131003A Taletrectinib free base Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09634 NTRK3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09635 Ntrk3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09636 Ntrk3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ntrk3 NCBI NCBI:4916
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