2. Gene
  3. Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：真核翻译起始因子 2α 激酶 3

种属: Rattus norvegicus

同用名: PEK

基因 ID: 29702 | 基因类型: protein coding

关于 Eif2ak3

Primary_assembly 4: 102,805,510-102,866,911 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 197 orthologues, 8 paralogues and is associated with 12 phenotypes. Biased expression in Thymus (RPKM 137.6), Kidney (RPKM 111.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 HSP90 蛋白结合活性和真核翻译起始因子 2alpha 激酶活性。参与应对压力的翻译负调节；蛋白质自身磷酸化；以及对锰诱导的内质网应激的反应。位于细胞质的核周区。肺静脉闭塞性疾病的生物标志物。该基因的人类直系同源物与 Wolcott-Rallison 综合征和 1 型糖尿病有关。与人类 EIF2AK3（真核翻译起始因子 2 α 激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables HSP90 protein binding activity and eukaryotic translation initiation factor 2alpha kinase activity. Involved in negative regulation of translation in response to stress; protein autophosphorylation; and response to manganese-induced endoplasmic reticulum stress. Located in perinuclear region of cytoplasm. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak3 基因产物(1)

mRNA Protein Name
NM_031599.2 NP_113787.1 eukaryotic translation initiation factor 2-alpha kinase 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Hsp90 protein binding IDA
IDA: 通过直接分析推断
12446770 RGD
enables eukaryotic translation initiation factor 2alpha kinase activity IDA
IDA: 通过直接分析推断
9819435 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11781318 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of translation in response to stress IDA
IDA: 通过直接分析推断
9819435 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
9819435 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9819435 RGD
involved in response to manganese-induced endoplasmic reticulum stress IEP
IEP: 通过表达模式推断
23934647 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15936177 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Eif2ak3 蛋白结构

Luminal_EIF2AK3

Luminal_EIF2AK3: cd09768 (98 - 411)

PKc_like

PKc_like: cl21453 (578 - 666)

STKc_EIF2AK3_PERK

STKc_EIF2AK3_PERK: cd14048 (867 - 1066)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1108 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 2-alpha kinase 3

PRKR-like endoplasmic reticulum kinase

pancreatic eIF2-alpha kinase

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119240 CCT020312 Activator 99.28% 否
HY-RS04244 EIF2AK3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04245 Eif2ak3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04246 Eif2ak3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Eif2ak3 NCBI NCBI:9451
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