Lag3 - lymphocyte activating 3 Gene

种属: Rattus norvegicus

同用名: CD223

关于 Lag3

功能概要

Predicted to enable MHC class II protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]