VPREB3 - V-set pre-B cell surrogate light chain 3 Gene

中文名称：V-set 前 B 细胞替代轻链 3

种属: Homo sapiens

同用名: 8HS20; N27C7-2

关于 VPREB3

功能概要

该基因编码的蛋白质是小鼠 VpreB3 (8HS20) 蛋白质的人类直系同源物，被认为参与 B 细胞成熟，并可能在前 B 细胞受体 (pre-BCR) 的组装中发挥作用。虽然这种蛋白质在 B 细胞发育中的作用尚未阐明，但对这种蛋白质的鸡直系同源物的研究发现，当过表达时，这种蛋白质定位于内质网。这种蛋白质的小鼠直系同源物已被证明在前 B 细胞受体生物合成过程的早期与膜 mu 重链相关联。已在某些淋巴瘤中观察到该基因的表达。[RefSeq 提供，2015 年 4 月]

The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]