GPR132 - G protein-coupled receptor 132 Gene

中文名称：G 蛋白偶联受体 132

种属: Homo sapiens

同用名: G2A

关于 GPR132

功能概要

该基因编码鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体 (GPCR) 超家族的成员。这些受体是七次跨膜蛋白，可响应细胞外信号并激活细胞内信号转导通路。据报道，该蛋白质是溶血磷脂酰胆碱作用的受体，但 PubMedID：15653487 撤回了这一发现，而是表明该蛋白质是溶血磷脂酰胆碱作用的效应物。这种蛋白质可能具有质子感应活性，并且可能是氧化游离脂肪酸的受体。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]