2. Gene
  3. Hsp90aa1 - heat shock protein 90 alpha family class A member 1 Gene

Hsp90aa1 - heat shock protein 90 alpha family class A member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：热休克蛋白 90 α 家族 A 类成员 1

种属: Rattus norvegicus

同用名: Hsp86; Hsp90; Hspca

基因 ID: 299331 | 基因类型: protein coding

关于 Hsp90aa1

Primary_assembly 6: 129,702,383-129,707,268 reverse strand.mRatBN7.2:CM026979.1

This gene has 1 transcript (splice variant), 271 orthologues, 11 paralogues and is associated with 17 phenotypes. Biased expression in Brain (RPKM 2165.3), Testes (RPKM 1934.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 Rho GDP 解离抑制剂结合活性；核苷酸结合活性；和磺酰脲受体结合活性。参与多个过程，包括心肌细胞凋亡过程； lamellipodium 组件的正调节；以及蛋白质输入细胞核的正调控。位于几种细胞成分中，包括基底外侧质膜；刷状缘膜；和精子线粒体鞘。部分含蛋白质复合物。门静脉高压症的生物标志物。与人类 HSP90AA1（热休克蛋白 90 α 家族 A 类成员 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Rho GDP-dissociation inhibitor binding activity; nucleotide binding activity; and sulfonylurea receptor binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; positive regulation of lamellipodium assembly; and positive regulation of protein import into nucleus. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and sperm mitochondrial sheath. Part of protein-containing complex. Biomarker of portal hypertension. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsp90aa1 基因产物(1)

mRNA Protein Name
NM_175761.2 NP_786937.1 heat shock protein HSP 90-alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
12755697 RGD
enables CTP binding IDA
IDA: 通过直接分析推断
12755697 RGD
enables GTP binding IDA
IDA: 通过直接分析推断
12755697 RGD
enables Rho GDP-dissociation inhibitor binding IDA
IDA: 通过直接分析推断
19910677 RGD
enables UTP binding IDA
IDA: 通过直接分析推断
12755697 RGD
enables dATP binding IDA
IDA: 通过直接分析推断
12755697 RGD
enables mRNA binding IDA
IDA: 通过直接分析推断
19703590 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15001530 RGD
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
8943293 RGD
enables sulfonylurea receptor binding IPI
IPI: 通过物理相互作用推断
20427569 RGD
enables tau protein binding IPI
IPI: 通过物理相互作用推断
19363271 RGD
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
20427569 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac muscle cell apoptotic process IEP
IEP: 通过表达模式推断
21620734 RGD
involved in neuron migration IMP
IMP: 通过突变表型推断
15302889 RGD
involved in positive regulation of cardiac muscle contraction IEP
IEP: 通过表达模式推断
21620734 RGD
involved in positive regulation of cell size IMP
IMP: 通过突变表型推断
20980790 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: 通过突变表型推断
15302889 RGD
involved in positive regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
20980790 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
EXP: 通过实验结果推断
15152036 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: 通过直接分析推断
15152036 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
22860061 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
15229138 RGD
involved in response to salt stress IEP
IEP: 通过表达模式推断
15497505 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
24478030 RGD
involved in skeletal muscle contraction IEP
IEP: 通过表达模式推断
20851858 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15497505 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
15497505 RGD
located in brush border membrane IDA
IDA: 通过直接分析推断
15497505 RGD
located in cell surface IDA
IDA: 通过直接分析推断
15302889 RGD
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
15497505 RGD
located in myelin sheath IDA
IDA: 通过直接分析推断
17960831 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
20796173 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
20796173 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
20796173 RGD
located in sperm flagellum IDA
IDA: 通过直接分析推断
24478030 RGD
located in sperm mitochondrial sheath IDA
IDA: 通过直接分析推断
24478030 RGD
located in sperm plasma membrane IDA
IDA: 通过直接分析推断
24478030 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hsp90aa1 蛋白结构

PRK14083

PRK14083: cl42520 (17 - 732)

  • 0
  • 200
  • 400
  • 600
  • 733 a.a.
蛋白主名 其他名称

heat shock protein HSP 90-alpha

HSP 86

heat shock 86 kDa

heat shock protein 1, alpha

heat shock protein 86

heat shock protein 90, alpha (cytosolic), class A member 1

heat shock protein 90kDa alpha family class A member 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06415 HSP90AA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06416 Hsp90aa1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06417 Hsp90aa1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hsp90aa1 NCBI NCBI:3320
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