1. Gene
  2. Mmp1 - matrix metallopeptidase 1 Gene

Mmp1 - matrix metallopeptidase 1 Gene

中文名称:基质金属肽酶 1

种属: Rattus norvegicus

同用名: Clgn; MMP-1; Mmp1a

基因 ID: 300339 | 基因类型: protein coding

关于 Mmp1

Primary_assembly 8: 4,658,588-4,679,097 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 308 orthologues, 23 paralogues and is associated with 100 phenotypes. Biased expression in Adrenal (RPKM 1.), Spleen (RPKM 1.) and 4 other tissues.

功能概要

该基因编码的蛋白可启动肽酶活性。参与多个过程,包括细胞对细胞因子刺激的反应;女性性腺发育;和细胞迁移的正调控。位于细胞质和细胞外空间。用于研究多种疾病,包括动脉疾病(多种);退行性椎间盘疾病;肝硬化;肺纤维化;和溃疡性结肠炎。多种疾病的生物标志物,包括慢性阻塞性肺病;肝硬化;脊柱侧弯;肌腱炎;和 2 型糖尿病。该基因的人类直系同源物与多种疾病有关,包括动脉疾病(多种);女性生殖器官癌(多发性);内在性心肌病(多发性);阻塞性肺病(多发性);和泌尿系统癌症(多发性)。与人 MMP1(基质金属肽酶 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ Cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system Cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mmp1 基因产物(1)

mRNA Protein Name
NM_001134530.1 NP_001128002.1 interstitial collagenase precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase activity IDA
IDA: 通过直接分析推断
8531210 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
21846328 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to alkaloid IEP
IEP: 通过表达模式推断
21108488 RGD
involved in cellular response to fluid shear stress IEP
IEP: 通过表达模式推断
19880665 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
22410640 RGD
involved in cellular response to iron(III) ion IEP
IEP: 通过表达模式推断
21683124 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
21683124 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
21811993 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: 通过表达模式推断
20564215 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
22410640 RGD
involved in cellular response to vitamin D IEP
IEP: 通过表达模式推断
22064970 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19847888 RGD
involved in luteinization IEP
IEP: 通过表达模式推断
8835383 RGD
involved in luteolysis IEP
IEP: 通过表达模式推断
8835383 RGD
involved in positive regulation of fibroblast migration IMP
IMP: 通过突变表型推断
19465549 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
19465549 RGD
involved in response to inactivity IEP
IEP: 通过表达模式推断
20826544 RGD
involved in response to indole-3-methanol IEP
IEP: 通过表达模式推断
20880187 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
21488874 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
23325540 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
22410640 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Mmp1 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (25 - 83)

Peptidase_M10

Peptidase_M10: pfam00413 (104 - 258)

HX

HX: cd00094 (272 - 463)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
蛋白主名 其他名称

interstitial collagenase

fibroblast collagenase

matrix metallopeptidase 1a

matrix metalloproteinase 1

matrix metalloproteinase 1a (interstitial collagenase)

myocardial collagenase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp1 NCBI NCBI:4312
Mus musculus Mmp1 NCBI