Chondroitin sulfate sodium (from shark cartilage)  (Synonyms: 硫酸软骨素钠; Chondroitin polysulfate sodium (from shark cartilage))

Chondroitin sulfate sodium (from shark cartilage), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs^[1][2][3][4].

Chondroitin sulfate sodium (from shark cartilage) 是一类硫酸化糖胺聚糖，是由糖醛酸和N-乙酰己糖胺组成的重复二糖单元组成的线性多糖。包括寄生虫、细菌和病毒在内的多种病原体已显示利用细胞表面 Chondroitin sulfate 链附着并感染宿主细胞^[1]。
Chondroitin sulfate 天然存在于结缔组织的细胞外基质中，例如骨骼、软骨、皮肤、韧带和肌腱。Chondroitin sulfate 已显示出一系列有益作用：抗炎作用、II 型胶原蛋白和蛋白多糖的增加、骨吸收减少以及软骨细胞中更好的合成代谢/分解代谢平衡^[2]。
体外研究中使用了大范围的 Chondroitin sulfate 浓度 (例如 12.5 至 2000 mg/mL，但通常低于 200 mg/mL)。Chondroitin suLfate (200 mg/mL) 降低软骨细胞对单核苷酸多态性诱导的细胞凋亡的敏感性^[3]。
Chondroitin sulfate 可减少炎症介质和细胞凋亡过程，并能够减少炎症细胞因子、iNOS、MMPs的蛋白质生成^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

聚合蛋白中 Chondroitin sulfate 的高含量在使软骨在各种负载条件下抵抗拉伸应力方面起着重要作用，为该组织提供了阻力和弹性。研究表明，Chondroitin sulfate 会干扰关节组织结构变化的进展，并用于处理骨关节炎患者^[3]。
Chondroitin sulfate 主要以 800 至 1200 毫克/天的剂量口服给药。Chondroitin sulfate 被胃肠道迅速吸收。被吸收的 Chondroitin sulfate 以 10% 的 Chondroitin sulfate 和 90% 的解聚低分子量衍生物的形式到达血室^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9082-07-9

固体

White to off-white

硫酸软骨素钠

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Mikami T, et al. Biosynthesis and function of chondroitin sulfate. Biochim Biophys Acta. 2013 Oct;1830(10):4719-33.  [Content Brief]

  [2]. Monfort J, et al. Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis. 2008 Jun;67(6):735-40.  [Content Brief]

  [3]. Martel-Pelletier J, et al.Discrepancies in composition and biological effects of different formulations of chondroitin sulfate. Molecules. 2015 Mar 6;20(3):4277-89.  [Content Brief]

  [4]. Campo GM, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92.  [Content Brief]

  [5]. Henrotin Y, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinicalrecommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48.  [Content Brief]