2. Gene
  3. H1-0 - H1.0 linker histone Gene

H1-0 - H1.0 linker histone Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：H1.0 接头组蛋白

种属: Homo sapiens

同用名: H10; H1.0; H1F0; H1FV

基因 ID: 3005 | 基因类型: protein coding

关于 H1-0

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,805,229-37,807,432 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 9 paralogues.

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。核小体由大约 146 bp 的 DNA 组成，包裹在由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成的组蛋白八聚体周围。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。该基因是无内含子的，编码一种复制独立组蛋白，该组蛋白是组蛋白 H1 家族的一员。[RefSeq 提供，2015 年 10 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

H1-0 基因产物(1)

mRNA Protein Name
NM_005318.4 NP_005309.1 histone H1.0
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
15911621 GOA
enables nucleosome binding IPI
IPI: 通过物理相互作用推断
35377618 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9499053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heterochromatin formation IGI
IGI: 通过遗传相互作用推断
19158276 GOA
involved in positive regulation of transcription regulatory region DNA binding IMP
IMP: 通过突变表型推断
19158276 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
19882353 GOA
located in euchromatin IDA
IDA: 通过直接分析推断
15911621 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21383955 GOA
part of transcription repressor complex IDA
IDA: 通过直接分析推断
19158276 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

H1-0 蛋白结构

Linker_histone

Linker_histone: linker histone H1 and H5 family (25 - 97)

  • 0
  • 100
  • 194 a.a.
蛋白主名 其他名称

histone H1.0

H1 histone family member 0

H1-0 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
H1-0 P07305 H2BC21 Homo sapiens Q16778
Anti Tag CoIP
35271311
种属内
H1-0 P07305 H2BC21 Homo sapiens Q16778
Crosslink
30021884
种属内
H1-0 P07305 H2AC21 Homo sapiens Q8IUE6
Anti Tag CoIP
35271311
种属内
H1-0 P07305 H2AC14 Homo sapiens Q99878
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 H1-0 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74887 Histone H1 Protein, Human (His) P07305-1 (M1-K194) ≥95%

关联疾病

疾病名称 别名
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P5831 Biotin-H10 Inhibitor 98.04% 否
HY-117889 PARP14 inhibitor H10 98.04% 否
HY-117046A AVN-101 hydrochloride 99.59% 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-RS05944 H1-0 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus H1-0 VGNC VGNC:84027
Mus musculus H1-0 MGD MGI:95893
Rattus norvegicus H1-0 RGD RGD:2777
Bos taurus H1-0 VGNC VGNC:83619
Macaca mulatta H1-0 VGNC VGNC:109666
Others H1-0 NCBI
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