HCRTR2 - hypocretin receptor 2 Gene

中文名称：伪君子受体 2

种属: Homo sapiens

同用名: OX2R; OXR2; ORXR2

基因 ID: 3062 | 基因类型: protein coding

关于 HCRTR2

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,106,469-55,284,713 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 16 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是参与摄食行为调节的 G 蛋白偶联受体。编码的蛋白质与下丘脑神经肽食欲素 A 和食欲素 B 结合。相关基因 (HCRTR1) 编码选择性结合食欲素 A 的 G 蛋白偶联受体。[RefSeq 提供，2009 年 1 月]

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

HCRTR2 基因产物(3)

mRNA	Protein	Name
NM_001526.5	NP_001517.2	orexin receptor type 2
NM_001384272.1	NP_001371201.1	orexin receptor type 2
XM_017010798.2	XP_016866287.1	orexin receptor type 2 isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables orexin receptor activity	IDA IDA: 通过直接分析推断	26950369	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in neuropeptide signaling pathway	IDA IDA: 通过直接分析推断	26950369	GOA
involved in regulation of cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	26950369	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	26950369	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HCRTR2 蛋白结构

7tm_1

Orexin_rec2

0
100
200
300
400
444 a.a.

蛋白主名

其他名称

orexin receptor type 2

hypocretin (orexin) receptor 2	hypocretin receptor type 2
orexin type-2 receptor

关联疾病

疾病名称

别名

Periodic Limb Movement Disorder

Nocturnal Myoclonus Syndrome

Nocturnal Myoclonus

Headache

Headache Disorder

Cluster Headache

Headache, Cluster

Von Economo'S Disease

Encephalitis Lethargica	Von Economo Encephalitis
Von Economo Disease

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Recurrent Hypersomnia

Primary Recurrent Hypersomnia	Hypersomnia Recurrent
Disorders Of Excessive Somnolence	Hypersomnia, Recurrent

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06054	HCRTR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06055	Hcrtr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06056	Hcrtr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	HCRTR2	VGNC	VGNC:73357
Bos taurus	HCRTR2	VGNC	VGNC:29782
Mus musculus	HCRTR2	MGD	MGI:2680765
Felis catus	HCRTR2	VGNC	VGNC:67545
Canis familiaris	HCRTR2	VGNC	VGNC:41624
Rattus norvegicus	HCRTR2	RGD	RGD:2788
Others	HCRTR2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HCRTR2 - hypocretin receptor 2 Gene

关于 HCRTR2

功能概要

HCRTR2 基因产物(3)

HCRTR2 蛋白结构

关联疾病

直系同源

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HCRTR2 - hypocretin receptor 2 Gene

关于 HCRTR2

功能概要

HCRTR2 基因产物(3)

HCRTR2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z