1. Gene
  2. CD209 - CD209 molecule Gene

CD209 - CD209 molecule Gene

中文名称:CD209 分子

种属: Homo sapiens

同用名: CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN

基因 ID: 30835 | 基因类型: protein coding

关于 CD209

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,739,993-7,747,534 (from NCBI)

This gene has 11 transcripts (splice variants), 891 orthologues, 14 paralogues and is associated with 68 phenotypes. Broad expression in placenta (RPKM 11.4), lymph node (RPKM 9.5) and 17 other tissues.

功能概要

该基因编码一种 C 型凝集素,该凝集素在细胞粘附和病原体识别中发挥作用。这种受体识别范围广泛的对公众健康有重大影响的进化上不同的病原体,包括麻风病和结核分枝杆菌、埃博拉病毒、丙型肝炎病毒、HIV-1 和登革热病毒,以及 SARS-CoV 急性呼吸系统综合症冠状病毒。该蛋白质分为四个不同的结构域:C 末端碳水化合物识别结构域、灵活的串联重复颈部结构域、跨膜区域和参与内化的 N 末端胞质结构域。该基因在序列和功能方面与邻近基因 CLEC4M (基因 ID:10332) (也称为 L-SIGN) 密切相关。这两个基因在病毒识别和表达模式上有所不同,该基因在树突细胞表面表现出高表达。颈部多态性与防止 HIV-1 感染有关,而该基因启动子中的单核苷酸多态性与对传染病的不同抵抗力、易感性和严重程度有关,包括与 SARS 严重程度相关的 rs4804803。[RefSeq 提供,2020 年 5 月]

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 Infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]

CD209 基因产物(7)

mRNA Protein Name
NM_001144893.2 NP_001138365.1 CD209 antigen isoform 5
NM_001144894.2 NP_001138366.1 CD209 antigen isoform 6
NM_001144895.2 NP_001138367.1 CD209 antigen isoform 7
NM_001144896.2 NP_001138368.1 CD209 antigen isoform 3
NM_001144897.2 NP_001138369.1 CD209 antigen isoform 4
NM_001144899.2 NP_001138371.1 CD209 antigen isoform 8
NM_021155.4 NP_066978.1 CD209 antigen isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12609975 GOA
enables virus receptor activity IDA
IDA: 通过直接分析推断
22156524 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell adhesion IDA
IDA: 通过直接分析推断
12421943 GOA
involved in positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
12421943 GOA
involved in positive regulation of viral life cycle IMP
IMP: 通过突变表型推断
22673088 GOA
acts upstream of or within regulation of T cell proliferation IDA
IDA: 通过直接分析推断
12456590 GOA
involved in symbiont entry into host cell IDA
IDA: 通过直接分析推断
24623090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
24942581 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12421943 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CD209 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (274 - 379)

  • 0
  • 100
  • 200
  • 300
  • 404 a.a.
蛋白主名 其他名称

CD209 antigen

C-type lectin domain family 4 member L

CD209 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD209 Q9NNX6 VAC14 Homo sapiens Q08AM6 25416956
种属内
CD209 Q9NNX6 VAC14 Homo sapiens Q08AM6 29892012
种属间
CD209 Q9NNX6 Q03463-PRO_0000278734 Hepatitis C virus Q03463-PRO_0000278734
SPR
12609975
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD209 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70110 DC-SIGN/CD209 Protein, Human (HEK293, Fc) Q9NNX6-1 (Q59-A404) ≥95%

CD209 抗体

目录号 产品名 应用 反应物种
HY-P83614 CD209 Antibody (YA3359) WB Human

关联疾病

疾病名称 别名
Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever

Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids

Rift Valley Fever

Rfv - [Rift Valley Fever]

Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis

Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis

Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots

West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever

Dengue Disease

Dengue Fever

Dengue

Df

Dengue Shock Syndrome

Dengue Virus Infection

Breakbone Fever

Classic Dengue

Classical Dengue

Dengue Hemorrhagic Fever

Hemorrhagic Dengue

Philippine Hemorrhagic Fever

Singapore Hemorrhagic Fever

Thai Hemorrhagic Fever

Severe Dengue

Dengue Fever Without Warning Signs

Dengue Haemorrhagic Fever Grade 1

Dengue Haemorrhagic Fever Without Warning Signs

Bangkok Haemorrhagic Fever

Singapore Haemorrhagic Fever

Thailand Haemorrhagic Fever

Southeast Asia Haemorrhagic Fever

Dhf -[Dengue Haemorrhagic Fever]

Dengue Fever With Warning Signs

Dengue Haemorrhagic Fever With Warning Signs

Dengue Haemorrhagic Fever Grade 2

Philippine Haemorrhagic Fever

Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos

Syphilis

Chancre

Syphilitic Chancre

Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Zika Fever

Zika Virus Infection

Zika Virus Disease

Zika Virus

Zika Virus Fever

Mosquito-Borne Viral Fever, Zika

Papilloma

Papillomatosis

Lymphadenitis

Acute Lymphadenitis

Chronic Lymphadenitis

Adenitis

Chronic Adenitis

Acute Adenitis

Inflammation Of Lymph Node

Adenitis Nos

Inflammation Of Gland

Lymphatic Gland Inflammation

Lymph Gland Inflammation

Polyadenitis

Chronic Adenitis Of Any Lymph Node Except Mesenteric

Chronic Lymphadenitis Except Mesenteric

Chronic Non-Specific Lymphadenitis

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Paracoccidioidomycosis

Mucocutaneous-Lymphangitic Paracoccidioidomycosis

Paracoccidioidal Mycosis

Lobo Disease

Lutz-Splendore-Almeida Disease

Pcm

Paracoccidioidal Granuloma

South American Blastomycosis

Lobomycosis

Brazilian Blastomycosis

Lutz Disease

Brazilian Blastomycotic

South American Blastomyces Infection

Paracoccidioides Brasiliensis Infection

Paracoccidioidomycosis Unspecified

Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus

Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Severe Acute Respiratory Syndrome

Sars

Sars-Cov Infection

Sars-1

Sar Deficiency

Sars - [Severe Acute Respiratory Syndrome]

Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus

Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

Dengue Hemorrhagic Fever

Severe Dengue

Dengue Haemorrhagic Fever

Dhf

Severe Dengue Haemorrhagic Fever

Severe Dengue Fever

Dengue Shock Syndrome

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis

Encephalitis, Tick-Borne

Central European Encephalitis

Far Eastern Tbe

Russian Spring-Summer Encephalitis

Taiga Encephalitis

West-Siberian Encephalitis

Western European Tick-Borne Encephalitis

Tbe

Encephalitis Tick-Borne

Encephalitis, Central European

Encephalitis, Far Eastern Russian

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Mouth Disease

Mouth Diseases

Mouth Disorders

Dengue Shock Syndrome

Dss

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Invasive Aspergillosis

Aspergillosis Invasive

Miyoshi Muscular Dystrophy 3

MMD3

Miyoshi Myopathy 3

Distal Anoctaminopathy

Miyoshi Muscular Dystrophy Type 3

Dystrophy, Muscular, Miyoshi, Type 3

Cutaneous Leishmaniasis

Diffuse Cutaneous Leishmaniasis

Asian Desert Cutaneous Leishmaniasis

Leishmaniasis, Cutaneous

Leproid Leishmaniasis

Leishmaniasis Diffuse Cutaneous

Leishmaniasis Cutaneous

Ethiopian Cutaneous Leishmaniasis

Old World Cutaneous Leishmaniasis

Tuberculoid Leprosy

Smooth Leprosy

Type T Leprosy

Leprosy Tuberculoid

Leprosy, Tuberculoid

West Nile Fever
Murray Valley Encephalitis

Australian Encephalitis

Australian X Disease

Encephalitis Australia

Murray River Encephalitis

Australian Arboencephalitis

Australian X Disorder

Mve - [Murray Valley Encephalitis]

Lassa Fever

Lf

Lassa Hemorrhagic Fever

Lf - [Lassa Fever]

Lepromatous Leprosy

Leprosy, Lepromatous

Type L Leprosy

Leprosy Lepromatous

Leprosy 3

Leprosy

Leprosy, Susceptibility To, 3

Hansen'S Disease

Leprosy, Susceptibility To

Hansen Disease

Infection Due To Mycobacterium Leprae

LPRS3

Leprosy, Type 3

Anaesthesia Leprosy

Anaesthetic Leprosy

Maculoanaesthetic Leprosy

Macular Leprosy

Leprosy Unspecified

Fungal Infectious Disease

Mycoses

Mycosis

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Primary Bacterial Infectious Disease
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CD209 RGD RGD:1561104
Mus musculus CD209 NCBI
Macaca mulatta CD209 NCBI NCBI:574211
Others CD209 NCBI