HLA-DOA - major histocompatibility complex, class II, DO alpha Gene

中文名称：主要组织相容性复合体，II 类，DO α

种属: Homo sapiens

同用名: HLADZ; HLA-DNA; HLA-DZA

关于 HLA-DOA

功能概要

HLA-DOA 属于 HLA II 类α链旁系同源物。 HLA-DOA 与 HLA-DOB 形成异二聚体。异二聚体 HLA-DO 存在于 B 细胞的溶酶体中，并调节 HLA-DM 介导的肽加载到 MHC II 类分子上。与经典的 HLA II 类分子相比，该基因的序列变异非常小，尤其是在蛋白质水平上。[RefSeq 提供，2008 年 7 月]

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]