2. Gene
  3. HLA-DRA - major histocompatibility complex, class II, DR alpha Gene

HLA-DRA - major histocompatibility complex, class II, DR alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：主要组织相容性复合体，II 类，DR α

种属: Homo sapiens

同用名: HLA-DRA1

基因 ID: 3122 | 基因类型: protein coding

关于 HLA-DRA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,439,887-32,445,046 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 148 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 921.6), lung (RPKM 809.6) and 24 other tissues.

功能概要

HLA-DRA 是 HLA II 类α链旁系同源物之一。这种 II 类分子是由 α 和 β 链组成的异二聚体，它们都锚定在膜中。该分子在 B 淋巴细胞、树突状细胞和单核细胞/巨噬细胞等各种抗原呈递细胞的表面表达，并通过呈递细胞外蛋白肽，特别是病原体衍生肽，在免疫系统和反应中发挥核心作用肽到 T 细胞。 α 链约为 33-35 kDa，其基因包含 5 个外显子。外显子 1 编码前导肽，外显子 2 和 3 编码两个细胞外结构域，外显子 4 编码跨膜结构域和细胞质尾部。 DRA 在肽结合部分没有多态性，是 DRB1、DRB3、DRB4 和 DRB5 的唯一α链。[RefSeq 提供，2020 年 8 月]

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting Peptides derived from extracellular proteins, in particular, pathogen-derived Peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]

HLA-DRA 基因产物(1)

mRNA Protein Name
NM_019111.5 NP_061984.2 HLA class II histocompatibility antigen, DR alpha chain precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables T cell receptor binding IDA
IDA: 通过直接分析推断
29884618 GOA
enables peptide antigen binding IDA
IDA: 通过直接分析推断
1448172 GOA
enables polysaccharide binding IDA
IDA: 通过直接分析推断
21502329 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9354468 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antigen processing and presentation of endogenous peptide antigen via MHC class II IDA
IDA: 通过直接分析推断
15322540 GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: 通过直接分析推断
15265931 GOA
involved in antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IDA
IDA: 通过直接分析推断
21502329 GOA
involved in cognition IMP
IMP: 通过突变表型推断
23227193 GOA
involved in myeloid dendritic cell antigen processing and presentation IDA
IDA: 通过直接分析推断
29884618 GOA
involved in peptide antigen assembly with MHC class II protein complex IDA
IDA: 通过直接分析推断
1448172 GOA
involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IDA
IDA: 通过直接分析推断
28467828 GOA
involved in positive regulation of CD4-positive, alpha-beta T cell activation IDA
IDA: 通过直接分析推断
15265931 GOA
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
29884618 GOA
involved in positive regulation of memory T cell differentiation IDA
IDA: 通过直接分析推断
27591323 GOA
involved in regulation of T-helper cell differentiation IDA
IDA: 通过直接分析推断
15322540 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MHC class II protein complex IDA
IDA: 通过直接分析推断
1448172 GOA
part of MHC class II protein complex IMP
IMP: 通过突变表型推断
9354468 GOA
located in cell surface IDA
IDA: 通过直接分析推断
21502329 GOA
located in immunological synapse IDA
IDA: 通过直接分析推断
15322540 GOA
located in late endosome membrane IDA
IDA: 通过直接分析推断
9075930 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
9075930 GOA
located in lysosome IDA
IDA: 通过直接分析推断
8890155 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
8890155 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HLA-DRA 蛋白结构

MHC_II_alpha

MHC_II_alpha: Class II histocompatibility antigen, alpha domain (29 - 109)

C1-set

C1-set: Immunoglobulin C1-set domain (111 - 174)

  • 0
  • 100
  • 200
  • 229 a.a.
蛋白主名 其他名称

HLA class II histocompatibility antigen, DR alpha chain

MHC class II antigen DRA

HLA-DRA 抗体

目录号 产品名 应用 反应物种
HY-P83339 HLA DR Antibody (YA3084) WB, IHC-P, ICC/IF, FC Human

关联疾病

疾病名称 别名
Graham-Little-Piccardi-Lassueur Syndrome

Graham Little Syndrome

Graham Little-Piccardi-Lassueur Syndrome

Piccardi-Lassueur-Little Syndrome

Lichen Planus Follicularis
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Gallbladder Melanoma

Malignant Melanoma Of Gallbladder
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06210 HLA-DRA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HLA-DRA MGD MGI:95900
Rattus norvegicus HLA-DRA RGD RGD:1593283
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