HLA-DRB4 - major histocompatibility complex, class II, DR beta 4 Gene

中文名称：主要组织相容性复合体，II 类，DR beta 4

种属: Homo sapiens

同用名: DR4; DRB4; HLA-DRB; HLA-DR4B; HLA-DRB4*

关于 HLA-DRB4

功能概要

HLA-DRB4 属于 HLA II 类β链旁系同源物。这种 II 类分子是一种异二聚体，由一条 alpha (DRA) 和一条 beta (DRB) 链组成，它们都锚定在膜中。它通过呈递源自细胞外蛋白的肽在免疫系统中发挥核心作用。 II 类分子在抗原呈递细胞中表达。 β链约为 26-28 kDa，其基因包含 6 个外显子。外显子 1 编码前导肽，外显子 2 和 3 编码两个细胞外结构域，外显子 4 编码跨膜结构域，外显子 5 编码细胞质尾部。在 DR 分子内，β 链包含指定肽结合特异性的所有多态性。这些多态性的分型通常用于骨髓和肾移植。该基因有多个假基因。[RefSeq 提供，2020 年 2 月]

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting Peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]