2. Gene
  3. MAP3K7 - mitogen activated protein kinase kinase kinase 7 Gene

MAP3K7 - mitogen activated protein kinase kinase kinase 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：有丝分裂原活化蛋白激酶激酶激酶 7

种属: Rattus norvegicus

同用名: Tak1

基因 ID: 313121 | 基因类型: protein coding

关于 MAP3K7

Primary_assembly 5: 46,357,931-46,415,597 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 113.9), Thymus (RPKM 113.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 结合活性和 MAP 激酶激酶活性。参与MAPK级联；细胞内信号转导的正向调节；和蛋白质磷酸化。预测位于胞质溶胶中；质膜;和突触后密度。该基因的人类直系同源物与额干骺端发育不良 2 和前列腺癌有关。与人 MAP3K7（丝裂原活化蛋白激酶激酶激酶 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; positive regulation of intracellular signal transduction; and protein phosphorylation. Predicted to be located in cytosol; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate Cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

MAP3K7 基因产物(1)

mRNA Protein Name
NM_001107920.2 NP_001101390.2 mitogen-activated protein kinase kinase kinase 7
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
16183734 RGD
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
28821620 RGD
enables MAP kinase kinase kinase activity IDA
IDA: 通过直接分析推断
16183734 RGD
enables histone kinase activity IDA
IDA: 通过直接分析推断
16125722 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
35352799 RGD
enables protein serine/threonine kinase binding IDA
IDA: 通过直接分析推断
34733837 RGD
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
27956576 RGD
enables type II transforming growth factor beta receptor binding IPI
IPI: 通过物理相互作用推断
16360132 RGD
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
30760025 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in MAPK cascade IDA
IDA: 通过直接分析推断
16183734 RGD
involved in cellular response to angiotensin IDA
IDA: 通过直接分析推断
20659889 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
32734729 RGD
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
16125722 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
32581266 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
20659889 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
26002466 RGD
involved in negative regulation of voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
26584289 RGD
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
16183734 RGD
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
35078016 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
17947700 RGD
involved in positive regulation of cell cycle IMP
IMP: 通过突变表型推断
35078016 RGD
involved in positive regulation of cell size IMP
IMP: 通过突变表型推断
32971071 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
35078016 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
35078016 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
16125722 RGD
involved in response to angiotensin IEP
IEP: 通过表达模式推断
30854566 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
22388934 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP3K7 蛋白结构

STKc_TAK1

STKc_TAK1: cd14058 (41 - 291)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 606 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 7

TGF-beta activated kinase 1

mitogen-activated protein kinase kinase kinase 7-like

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136848 SM1-71 Inhibitor 96.09% 否
HY-RS08062 MAP3K7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08063 Map3k7 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08064 MAP3K7 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08065 MAP3K7CL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens MAP3K7 NCBI NCBI:6885
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