HLA-F - major histocompatibility complex, class I, F Gene

中文名称：主要组织相容性复合体，I 类，F 类

种属: Homo sapiens

同用名: HLAF; CDA12; HLA-5.4; HLA-CDA12

关于 HLA-F

功能概要

该基因属于 HLA I 类重链旁系同源物。它编码非经典重链，该重链与 β2 微球蛋白轻链形成异二聚体，重链锚定在膜中。与大多数其他 HLA 重链不同，该分子位于内质网和高尔基体中，少量存在于某些细胞类型的细胞表面。它包含一个发散的肽结合沟，被认为可以结合一部分用于免疫呈递的肽。该基因表现出很少的多态性。已发现该基因编码不同异构体的多个转录变体。由于剪接受体位点的改变，这些变体缺少在其他 HLA 旁系同源物的转录物中发现的编码外显子，从而导致更短的细胞质结构域。[RefSeq 提供，2008 年 7 月]

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most Other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of Peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from Other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]