2. Gene
  3. Mdm2 - MDM2 proto-oncogene Gene

Mdm2 - MDM2 proto-oncogene Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：MDM2 原癌基因

种属: Rattus norvegicus

基因 ID: 314856 | 基因类型: protein coding

关于 Mdm2

Primary_assembly 7: 53,290,664-53,314,915 reverse strand.mRatBN7.2:CM026980.1

This gene has 4 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 41 phenotypes. Biased expression in Testes (RPKM 24.7), Muscle (RPKM 22.2) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 p53 绑定活动；信号受体结合活性；和泛素蛋白连接酶活性。参与多个过程，包括细胞对激素刺激的反应；蛋白水解的负调节；和对生物碱的反应。位于几种细胞成分中，包括细胞质；核;和突触。用于研究鱼鳞病；创伤后应激障碍；和短暂性脑缺血。乳腺癌生物标志物；间歇性跛行；肝病;胰腺炎;和异常勃起。该基因的人类直系同源物与慢性粒细胞白血病有关；胶质母细胞瘤;肝细胞癌；胰腺导管癌；和肉瘤。与人类 MDM2 同源（MDM2 原癌基因）。 [由基因组资源联盟提供，2022 年 4 月]

Enables p53 binding activity; signaling receptor binding activity; and ubiquitin protein Ligase activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of proteolysis; and response to alkaloid. Located in several cellular components, including cytosol; nucleus; and synapse. Used to study ichthyosis; post-traumatic stress disorder; and transient cerebral ischemia. Biomarker of breast cancer; intermittent claudication; liver disease; pancreatitis; and priapism. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; glioblastoma; hepatocellular carcinoma; pancreatic ductal carcinoma; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Mdm2 基因产物(1)

mRNA Protein Name
NM_001108099.1 NP_001101569.1 E3 ubiquitin-protein ligase Mdm2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables p53 binding IPI
IPI: 通过物理相互作用推断
16330492 RGD
enables peroxisome proliferator activated receptor binding IPI
IPI: 通过物理相互作用推断
19103650 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
14642282 RGD
enables receptor serine/threonine kinase binding IPI
IPI: 通过物理相互作用推断
26228571 RGD
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
14642282 RGD
enables ubiquitin-protein transferase activity IMP
IMP: 通过突变表型推断
16330492 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to UV-C IEP
IEP: 通过表达模式推断
14558917 RGD
involved in cellular response to alkaloid IEP
IEP: 通过表达模式推断
19136059 RGD
involved in cellular response to antibiotic IEP
IEP: 通过表达模式推断
18469520 RGD
involved in cellular response to estrogen stimulus IEP
IEP: 通过表达模式推断
14667141 RGD
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
16091747 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
19638633 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
19819240 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: 通过表达模式推断
19850968 RGD
involved in cellular response to vitamin B1 IEP
IEP: 通过表达模式推断
15656374 RGD
involved in fibroblast activation IMP
IMP: 通过突变表型推断
28100501 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19103650 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
17881359 RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
19850968 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
19850968 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
23051735 RGD
involved in negative regulation of protein processing IMP
IMP: 通过突变表型推断
19638633 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
19103650 RGD
involved in positive regulation of protein export from nucleus IMP
IMP: 通过突变表型推断
17881359 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
21498419 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
21498419 RGD
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
14642282 RGD
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
16330492 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization EXP
EXP: 通过实验结果推断
14642282 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
14642282 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
14642282 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission EXP
EXP: 通过实验结果推断
14642282 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IDA
IDA: 通过直接分析推断
14642282 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IMP
IMP: 通过突变表型推断
14642282 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
14625023 RGD
involved in response to ether IEP
IEP: 通过表达模式推断
16790648 RGD
involved in response to formaldehyde IEP
IEP: 通过表达模式推断
18045764 RGD
involved in response to iron ion IEP
IEP: 通过表达模式推断
20019189 RGD
involved in response to magnesium ion IEP
IEP: 通过表达模式推断
15165363 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
17000718 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
16598789 RGD
involved in response to water-immersion restraint stress IDA
IDA: 通过直接分析推断
23174211 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19136059 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
14642282 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
14642282 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
14642282 RGD
is active in postsynaptic density EXP
EXP: 通过实验结果推断
21849563 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
21849563 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mdm2 蛋白结构

MDM2

MDM2: cd17672 (88 - 155)

zf-RanBP

zf-RanBP: pfam00641 (340 - 369)

mRING-HC-C2H2C4_MDM2

mRING-HC-C2H2C4_MDM2: cd16783 (475 - 530)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 532 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase Mdm2

MDM2 oncogene, E3 ubiquitin protein ligase

MDM2 proto-oncogene, E3 ubiquitin protein ligase

Mdm2 p53 binding protein homolog

double minute 2

p53 E3 ubiquitin protein ligase

transformed mouse 3T3 cell double minute 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128837 Nutlin carboxylic acid 98.63% 否
HY-168280 AS1411-C4-VH032 Degrader / 否
HY-128836 (4R,5S)-Nutlin carboxylic acid / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mdm2 NCBI NCBI:4193
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