2. Gene
  3. HNF4G - hepatocyte nuclear factor 4 gamma Gene

HNF4G - hepatocyte nuclear factor 4 gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肝细胞核因子 4γ

种属: Homo sapiens

同用名: NR2A2; NR2A3

基因 ID: 3174 | 基因类型: protein coding

关于 HNF4G

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:75,407,649-75,566,834 (from NCBI)

This gene has 5 transcripts (splice variants), 240 orthologues and 11 paralogues. Biased expression in small intestine (RPKM 55.0), duodenum (RPKM 46.4) and 5 other tissues.

功能概要

启用 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与 RNA 聚合酶 II 对转录的正调控。位于多个细胞成分中，包括细胞间桥；有丝分裂纺锤体;和核质。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HNF4G 基因产物(2)

mRNA Protein Name
NM_001330561.2 NP_001317490.1 hepatocyte nuclear factor 4-gamma isoform 2
NM_004133.5 NP_004124.5 hepatocyte nuclear factor 4-gamma isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
23896584 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12220531 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
23896584 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HNF4G 蛋白结构

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (11 - 79)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (124 - 312)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
蛋白主名 其他名称

hepatocyte nuclear factor 4-gamma

HNF-4-gamma

关联疾病

疾病名称 别名
Maturity-Onset Diabetes Of The Young, Type 1

Maturity-Onset Diabetes Of The Young Type 1

MODY1

Mild Juvenile Diabetes Mellitus

Mody, Type I

Diabetes Mellitus Type 2

Mody Type 1

Mody, Type 1

Maturity-Onset Diabetes Of The Young 1

Mody-1

Diabetes Of The Young, Maturity-Onset, Type 1
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06258 HNF4G Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus HNF4G VGNC VGNC:29892
Mus musculus HNF4G MGD MGI:1353604
Rattus norvegicus HNF4G RGD RGD:1310102
Macaca mulatta HNF4G VGNC VGNC:73493
Felis catus HNF4G VGNC VGNC:67604
Canis familiaris HNF4G VGNC VGNC:41726
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