1. Gene
  2. HTR3A - 5-hydroxytryptamine receptor 3A Gene

HTR3A - 5-hydroxytryptamine receptor 3A Gene

中文名称:5-羟色胺受体 3A

种属: Homo sapiens

同用名: HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R

基因 ID: 3359 | 基因类型: protein coding

关于 HTR3A

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,975,108-113,990,313 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 45 paralogues. Biased expression in lymph node (RPKM 3.0), appendix (RPKM 1.1) and 6 other tissues.

功能概要

该基因的产物属于配体门控离子通道受体超家族。该基因编码 5-羟色胺 (5-羟色胺) 3 型受体的 A 亚基,5-羟色胺是一种生物激素,具有神经递质、激素和有丝分裂原的作用。该受体在激活后会在神经元中引起快速的去极化反应。似乎 A 和 B 亚基的异聚组合对于提供该受体的全部功能特征是必要的,因为任一亚基单独导致受体具有非常低的电导和响应幅度。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2008 年 7 月]

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

HTR3A 基因产物(4)

mRNA Protein Name
NM_000869.6 NP_000860.3 5-hydroxytryptamine receptor 3A isoform b precursor
NR_046363.2
NM_001161772.3 NP_001155244.1 5-hydroxytryptamine receptor 3A isoform c
NM_213621.4 NP_998786.3 5-hydroxytryptamine receptor 3A isoform a precursor

HTR3A 蛋白结构

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (36 - 242)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (249 - 468)

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  • 400
  • 478 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 3A

5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

5-hydroxytryptamine receptor 3

5HT3 serotonin receptor

serotonin receptor 3A

serotonin-gated ion channel receptor

HTR3A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HTR3A P46098 HTR3E Homo sapiens A5X5Y0-3
Anti Bait CoIP
17392525
种属内
HTR3A P46098 HTR3E Homo sapiens A5X5Y0-3
Confocal
17392525
种属内
HTR3A P46098 HTR3E Homo sapiens A5X5Y0-3
Saturation Binding
17392525
种属内
HTR3A P46098 HTR3E Homo sapiens A5X5Y0-1
Pull Down
17392525
种属内
HTR3A P46098 HTR3E Homo sapiens A5X5Y0-1
Saturation Binding
17392525
种属内
HTR3A P46098 HTR3E Homo sapiens A5X5Y0-1
Anti Bait CoIP
17392525
种属内
HTR3A P46098 HTR3E Homo sapiens A5X5Y0-1
Confocal
17392525
种属内
HTR3A P46098 HTR3D Homo sapiens Q70Z44
Saturation Binding
17392525
种属内
HTR3A P46098 HTR3D Homo sapiens Q70Z44
Confocal
17392525
种属内
HTR3A P46098 HTR3D Homo sapiens Q70Z44
Anti Bait CoIP
17392525
种属内
HTR3A P46098 HTR3D Homo sapiens Q70Z44
Pull Down
17392525
种属内
HTR3A P46098 HTR3C Homo sapiens Q8WXA8
Pull Down
17392525
种属内
HTR3A P46098 HTR3C Homo sapiens Q8WXA8
Confocal
17392525
种属内
HTR3A P46098 HTR3C Homo sapiens Q8WXA8
Anti Bait CoIP
17392525
种属内
HTR3A P46098 HTR3C Homo sapiens Q8WXA8
Saturation Binding
17392525
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Trichothiodystrophy 7, Nonphotosensitive

TTD7

Nonphotosensitive Trichothiodystrophy 7

Trichothiodystrophy 7, Non-Photosensitive

Amnestic Disorder

Amnesia

Amnestic Syndrome

Korsakoff'S Psychosis Or Syndrome

Amnesic Syndrome

Amnestic Disorder In Conditions Classified Elsewhere

Korsakoff Psychosis Or Syndrome, Nonalcoholic

Nonalcoholic Organic Amnesic Syndrome

Organic Amnesic Syndrome

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Ischemic Colitis

Colitis, Ischemic

Irreversible Ischaemic Colitis

Motion Sickness

Airsickness

Carsickness

Seasickness

Travel Sickness

Riders' Vertigo

Gastroparesis

Gastroparesis Syndrome

Delayed Gastric Emptying

Gastric Atonia

Gastroparalysis

Stuttering

Stammering

Familial Persistent Stuttering

Stuttering, Familial Persistent 1

Sudden Infant Death Syndrome

SIDS

Sudden Infant Death Syndrome, Susceptibility To

Cot Death

Crib Death

Sudden Death Of Nonspecific Cause In Infancy

Sudden Infant Death

Death, Sudden, Syndrome, Infant

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Serotonin Syndrome

Serotonergic Syndrome

Serotonin Storm

Serotonin Toxicity

Serotonin Toxidrome

Malignant Carcinoid Syndrome

Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1

Neuroleptic Malignant Syndrome
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar

Hyperekplexia

Hereditary Hyperekplexia

Kok Disease

Congenital Stiff Man Syndrome

Familial Startle Disease

Sthe

Stiff-Baby Syndrome

Hereditary Hyperexplexia

Startle Disease

Exaggerated Startle Reaction

Hyperexplexia Hereditary

Startle Disease, Familial

Startle Reaction, Exaggerated

Stiff-Man Syndrome, Congenital

Stiff-Person Syndrome, Congenital

Congenital Stiff-Man Syndrome

Congenital Stiff-Person Syndrome

Familial Hyperekplexia

Startle Syndrome

Stiff Baby Syndrome

Hyperekplexia, Hereditary

Stiff-Person Syndrome

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Social Phobia

Phobia, Social

Phobia Social

Phobic Anxiety Disorder

Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos

Fibromyalgia

Diffuse Myofascial Pain Syndrome

Fibromyalgia Syndrome

Fibromyalgia-Fibromyositis Syndrome

Fibromyositis

Fibrositis

Fms

Myofascial Pain Syndrome

Myofascial Pain Syndromes

Constipation
Sialadenitis

Sialoadenitis

Adenitis, Salivary Gland

Salivary Gland Inflammation

Salivary Gland Adenitis

Sialitis

Inflammation Of Salivary Gland

Inflammation Of Salivary Duct Or Gland

Salivary Glandular Adenitis

Sialoangiitis

Sialoangitis

Sialodochitis

Irritable Bowel Syndrome

Irritable Colon

Psychogenic Ibs

Ibs - [Irritable Bowel Syndrome]

Spastic Bowel Syndrome

Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis

Headache

Headache Disorder

Brunner Syndrome

Monoamine Oxidase A Deficiency

Antisocial Behavior

BRNRS

Deficiency Of Monoamine Oxidase A

X-Linked Monoamine Oxidase Deficiency

Susceptibility To Antisocial Behavior

Antisocial Behavior, Susceptibility To

Anti-Social Behavior

Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder

Personality Disorder

Personality Disorders

Character Disorder

Personality

Specific Personality Disorders

Enduring Personality Change After Psychiatric Illness

Pedophilia

Paedophilia

Borderline Personality Disorder
Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior

Generalized Anxiety Disorder

Anxiety Generalized

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Cocaine Abuse

Cocaine-Related Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus HTR3A MGD MGI:96282
Felis catus HTR3A VGNC VGNC:67673
Bos taurus HTR3A VGNC VGNC:29998
Macaca mulatta HTR3A VGNC VGNC:73542
Canis familiaris HTR3A VGNC VGNC:41829
Rattus norvegicus HTR3A RGD RGD:61818