KCNK18 - potassium two pore domain channel subfamily K member 18 Gene

中文名称：钾二孔域通道亚科 K 成员 18

种属: Homo sapiens

同用名: TRIK; MGR13; TRESK; TRESK2; K2p18.1; TRESK-2

基因 ID: 338567 | 基因类型: protein coding

关于 KCNK18

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:117,197,489-117,210,299 (from NCBI)

This gene has 1 transcript (splice variant), 163 orthologues, 14 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

钾通道在许多细胞过程中发挥作用，包括维持动作电位、肌肉收缩、激素分泌、渗透压调节和离子流。该基因编码含有两个成孔 P 结构域的钾通道蛋白超家族成员，编码的蛋白质起外向整流钾通道的作用。已发现该基因的突变与先兆偏头痛有关。[RefSeq 提供，2011 年 1 月]

Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of Potassium Channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying Potassium Channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]

KCNK18 基因产物(1)

mRNA	Protein	Name
NM_181840.1	NP_862823.1	potassium channel subfamily K member 18

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables outward rectifier potassium channel activity	IDA IDA: 通过直接分析推断	12754259	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to pH	IDA IDA: 通过直接分析推断	12754259	GOA
involved in potassium ion export across plasma membrane	IDA IDA: 通过直接分析推断	12754259	GOA
involved in potassium ion transport	IDA IDA: 通过直接分析推断	20006580	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	20006580	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCNK18 蛋白结构

Ion_trans_2

0
100
200
300
384 a.a.

蛋白主名

其他名称

potassium channel subfamily K member 18

TWIK-related individual K+ channel

关联疾病

疾病名称

别名

Migraine With Or Without Aura 13

Migraine, With Or Without Aura, Susceptibility To, 13	MGR13
Migraine With Or Without Aura, Susceptibility To, 13	Migraine, With Or Without Aura 13

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome	BIBARS
Mental Retardation With Hypotonia And Facial Dysmorphism	Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome
Kcnk9 Imprinting Syndrome

Migraine Without Aura

Common Migraine	Migraine With Or Without Aura, Susceptibility To
Migraine Without Aura, Susceptibility To	Acute Migraine Without Aura

Advanced Sleep Phase Syndrome, Familial, 2

Advanced Sleep Phase Syndrome 2	FASPS2
Advanced Sleep-Phase Syndrome, Familial, 2	Familial Advanced Sleep Phase Syndrome 2
Sleep Phase Syndrome, Advanced, Familial, Type 2

Migraine, Familial Hemiplegic, 3

FHM3	Familial Hemiplegic Migraine 3
Mhp3	Migraine, Hemiplegic, Familial, Type 3

Brain Small Vessel Disease 1

Col4a1-Related Brain Small Vessel Disease With Hemorrhage	Col4a1-Related Familial Vascular Leukoencephalopathy
Col4a1-Related Retinal Arteriolar Tortuosity-Infantile Hemiparesis-Autosomal Dominant Leukoencephalopathy Syndrome	Autosomal Dominant Retinal Arteriolar Tortuosity, Infantile Hemiparesis, And Leukencephalopathy
Brain Small Vessel Disease With Axenfeld-Riegar Anomaly	Brain Small Vessel Disease With Hemorrhage
Brain Small Vessel Disease With Or Without Ocular Anomalies	Bsvd1
Infantile Hemiparesis	Leukoencephalopathy With Axenfeld-Riegar Anomaly

Migraine, Familial Hemiplegic, 2

FHM2	Mhp2
Migraine, Familial Basilar	Familial Hemiplegic Migraine 2
Familial Hemiplegic Migraine-2	Familiar Basilar Migraine
Migraine, Hemiplegic, Familial, Type 2

Migraine, Familial Hemiplegic, 1

FHM1	Mhp1
Fhm	Familial Hemiplegic Migraine 1
Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia	Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia
Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia	Migraine, Hemiplegic, Familial, Type 1
Hemiplegic Migraine, Familial Type 1

Familial Hemiplegic Migraine

Hemiplegic Migraine, Familial	Hemiplegic-Ophthalmoplegic Migraine
Fhm	Hemiplegic Migraine Familial

Spinocerebellar Ataxia 6

Spinocerebellar Ataxia Type 6	SCA6
Type 6 Spinocerebellar Ataxia	Spinocerebellar Ataxia-6
Ataxia, Spinocerebellar, Type 6

Retinal Arteries, Tortuosity Of

Retinal Arterial Tortuosity	Retinal Hemorrhage With Vascular Tortuosity
RATOR	Tortuosity Of Retinal Arteries
Retinal Arteriolar Tortuosity	Familial Isolated Retinal Arterial Tortuosity
Tortuosity, Arteries, Retinal

Brain Small Vessel Disease

Episodic Ataxia, Type 2

Episodic Ataxia Type 2	EA2
Apca	Capa
Cerebellopathy, Hereditary Paroxysmal	Acetazolamide-Responsive Hereditary Paroxysmal Cerebellar Ataxia
Cerebellar Ataxia, Paroxysmal, Acetazolamide-Responsive	Episodic Ataxia With Nystagmus
Ataxia, Episodic, With Nystagmus	Episodic Ataxia, Nystagmus-Associated
Ataxia, Familial Paroxysmal	Acetazolamide-Responsive Episodic Ataxia Syndrome
Acetazolamide-Responsive, Hereditary, Paroxysmal, Cerebellar Ataxia	Ataxia, Familial, Paroxysmal
Nystagmus-Associated Episodic Ataxia	Familial Paroxysmal Ataxia
Episodic Ataxia 2	Ea-2
Episodic Ataxia Nystagmus-Associated	Hereditary Paroxysmal Cerebellopathy
Ataxia, Episodic, Type 2

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Episodic Ataxia

Isaacs Syndrome	Neuromyotonia
Isaacs' Syndrome	Acquired Neuromyotonia
Continuous Muscle Fiber Activity Syndrome	Quantal Squander Syndrome
Isaacs-Mertens Syndrome	Ea Syndrome
Episodic Ataxia Syndrome	Isaac Syndrome
Isaac'S-Merten'S Syndrome	Isaac-Mertens Syndrome
Peripheral Nerve Hyperexcitability	Ea
Peripheral Nerve Hyperexcitability Syndrome	Ataxia, Episodic
Isaacs Neuromyotonia	Continuous Muscle Fibre Activity

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07157	KCNK18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	KCNK18	VGNC	VGNC:30471
Rattus norvegicus	KCNK18	RGD	RGD:1303091
Canis familiaris	KCNK18	VGNC	VGNC:42273
Macaca mulatta	KCNK18	VGNC	VGNC:106065
Mus musculus	KCNK18	MGD	MGI:2685627

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KCNK18 - potassium two pore domain channel subfamily K member 18 Gene

关于 KCNK18

功能概要

KCNK18 基因产物(1)

KCNK18 蛋白结构

关联疾病

直系同源

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KCNK18 - potassium two pore domain channel subfamily K member 18 Gene

关于 KCNK18

功能概要

KCNK18 基因产物(1)

KCNK18 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

S

T

X

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