1. Gene
  2. IGFBP7 - insulin like growth factor binding protein 7 Gene

IGFBP7 - insulin like growth factor binding protein 7 Gene

中文名称:胰岛素样生长因子结合蛋白 7

种属: Homo sapiens

同用名: AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1

基因 ID: 3490 | 基因类型: protein coding

关于 IGFBP7

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:57,030,773-57,110,385 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in kidney (RPKM 607.4), gall bladder (RPKM 382.6) and 21 other tissues.

功能概要

该基因编码胰岛素样生长因子 (IGF) 结合蛋白 (IGFBP) 家族的成员。 IGFBP 以高亲和力结合 IGF,调节体液和组织中 IGF 的可用性,并调节 IGF 与其受体的结合。该蛋白以相对低的亲和力结合 IGF-I 和 IGF-II,属于低亲和力 IGFBPs 的一个亚家族。它还刺激前列环素的产生和细胞粘附。已经描述了该基因编码不同亚型的选择性剪接转录变体,并且一个变体与视网膜动脉大动脉瘤 (PMID:21835307) 相关。[RefSeq 提供,2011 年 12 月]

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

IGFBP7 基因产物(2)

mRNA Protein Name
NM_001253835.2 NP_001240764.1 insulin-like growth factor-binding protein 7 isoform 2 precursor
NM_001553.3 NP_001544.1 insulin-like growth factor-binding protein 7 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9388210 GOA
enables receptor ligand activity IDA
IDA: 通过直接分析推断
38218180 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IDA
IDA: 通过直接分析推断
38218180 GOA
involved in cell adhesion IDA
IDA: 通过直接分析推断
8117260 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IGFBP7 蛋白结构

IGFBP

IGFBP: Insulin-like growth factor binding protein (32 - 87)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (116 - 156)

I-set

I-set: Immunoglobulin I-set domain (160 - 265)

  • 0
  • 100
  • 200
  • 282 a.a.
蛋白主名 其他名称

insulin-like growth factor-binding protein 7

IGF-binding protein 7

重组 IGFBP7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70726 IGFBP-7 Protein, Human (HEK293, His) Q16270-1 (S27-L282) ≥95%
HY-P73142 IGFBP-7 Protein, Human (HEK293, Fc) Q16270-1 (S27-L282) ≥95%

IGFBP7 抗体

目录号 产品名 应用 反应物种
HY-P83334 IGFBP7 Antibody (YA3079) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis

Familial Retinal Arterial Macroaneurysm

RAMSVPS

Fram

Retinal Arterial Macroaneurysm And Supravalvular Pulmonic Stenosis

Macroaneurysm, Arterial, Retinal, With Supravalvular Pulmonic Stenosis

Diabetic Angiopathy

Diabetic Angiopathies

Diabetic Peripheral Angiopathy

Diabetic Vascular Disorder

Pulmonic Stenosis

Valvular Pulmonic Stenosis

Congenital Pulmonary Valvar Stenosis

Congenital Stenosis Of Pulmonary Valve

Pulmonary Valve Stenosis

Pulmonary Stenosis

Congenital Pulmonary Valve Stricture

Congenital Pulmonary Valve Stenosis

Spinocerebellar Ataxia, Autosomal Recessive 12

Autosomal Recessive Spinocerebellar Ataxia 12

SCAR12

Spinocerebellar Ataxia With Mental Retardation And Epilepsy

Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency

Autosomal Recessive Spinocerebellar Ataxia Type 12

Spinocerebellar Ataxia, Autosomal Recessive, 12

Ataxia, Spinocerebellar, Autosomal Recessive, Type 12

Viral Laryngitis
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Anuria

Suppression Of Urinary Secretion

Acute Kidney Tubular Necrosis

Acute Tubular Necrosis

Acute Renal Failure With Tubular Necrosis

Acute Tubule Necrosis

Acute Renal Failure With Lesion Of Tubular Necrosis

Atn - Acute Tubular Necrosis

Tubular Necrosis Acute

Kidney Tubular Necrosis, Acute

Acute Renal Tubular Necrosis

Acute Tubular Nephrosis

Ischaemic Acute Tubular Necrosis

Ischaemic Tubular Necrosis

Kidney Tubular Necrosis

Lower Nephron Nephrosis

Necrotising Renal Oedema

Renal Tubular Necrosis

Toxic Tubular Necrosis

Tubular Kidney Necrosis

Tubular Necrosis Nos

Tubular Nephrosis

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Diabetes Mellitus

Diabetes

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IGFBP7 VGNC VGNC:73578
Canis familiaris IGFBP7 VGNC VGNC:41908
Rattus norvegicus IGFBP7 RGD RGD:1306201
Bos taurus IGFBP7 VGNC VGNC:30089
Mus musculus IGFBP7 MGD MGI:1352480
Felis catus IGFBP7 VGNC VGNC:78514
Others IGFBP7 NCBI