2. Gene
  3. IL1RAP - interleukin 1 receptor accessory protein Gene

IL1RAP - interleukin 1 receptor accessory protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 1 受体辅助蛋白

种属: Homo sapiens

同用名: IL1R3; C3orf13; IL-1RAcP

基因 ID: 3556 | 基因类型: protein coding

关于 IL1RAP

Cytogenetic location: 3q28 Genomic coordinates (GRCh38): 3:190,514,085-190,659,750 (from NCBI)

This gene has 19 transcripts (splice variants), 199 orthologues and 10 paralogues. Broad expression in liver (RPKM 11.2), placenta (RPKM 7.8) and 21 other tissues.

功能概要

该基因编码白细胞介素 1 受体复合物的一个成分，它启动导致白细胞介素 1 反应基因激活的信号事件。该基因的选择性剪接导致膜结合和可溶性亚型的 C 末端不同。在急性期诱导或应激期间，可溶性与膜结合形式的比例增加。[RefSeq 提供，2018 年 7 月]

This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]

IL1RAP 基因产物(9)

mRNA Protein Name
NM_001167928.2 NP_001161400.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_001167929.2 NP_001161401.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_001167930.2 NP_001161402.1 interleukin-1 receptor accessory protein isoform 2 precursor
NM_001167931.2 NP_001161403.1 interleukin-1 receptor accessory protein isoform 3 precursor
NM_001364879.1 NP_001351808.1 interleukin-1 receptor accessory protein isoform 3 precursor
NM_001364880.2 NP_001351809.1 interleukin-1 receptor accessory protein isoform 4 precursor
NM_001364881.2 NP_001351810.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_002182.4 NP_002173.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_134470.4 NP_608273.1 interleukin-1 receptor accessory protein isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables coreceptor activity IDA
IDA: 通过直接分析推断
10854325 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interleukin-1-mediated signaling pathway IDA
IDA: 通过直接分析推断
9065432 GOA
involved in interleukin-33-mediated signaling pathway IDA
IDA: 通过直接分析推断
17675517 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL1RAP 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (85 - 122)

Ig_2

Ig_2: Immunoglobulin domain (158 - 233)

TIR

TIR: TIR domain (408 - 544)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 570 a.a.
蛋白主名 其他名称

interleukin-1 receptor accessory protein

IL-1 receptor accessory protein

重组 IL1RAP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72565 IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His) Q9NPH3-1 (S21-E359) ≥95%
HY-P77413 IL-1RAcP/IL-1 R3 Protein, Human (HEK293, Fc) Q9NPH3-1 (S21-E359) ≥95%
HY-P78146 IL-1RAcP/IL-1 R3 Protein, Human (Biotinylated, HEK293, His-Avi) Q9NPH3-1 (S21-E359) ≥95%
HY-P78463 IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His-Avi) Q9NPH3-1 (S21-E359) ≥95%

关联疾病

疾病名称 别名
Indolent Plasma Cell Myeloma

Indolent Myeloma

Indolent Multiple Myeloma
Chromosome Xp21 Deletion Syndrome

Complex Glycerol Kinase Deficiency

Xp21 Microdeletion Syndrome

Monosomy Xp21

Xp21 Deletion Syndrome

Complex Gkd

Del

Xp21 Contiguous Gene Deletion Syndrome

Glycerol Kinase Deficiency - Contiguous Gene Syndrome
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99379 Nidanilimab (Nadunolimab) Inhibitor 99.90% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06722 IL1RAP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IL1RAP RGD RGD:2893
Macaca mulatta IL1RAP VGNC VGNC:73718
Felis catus IL1RAP VGNC VGNC:97465
Mus musculus IL1RAP MGD MGI:104975
Canis familiaris IL1RAP VGNC VGNC:41960
Bos taurus IL1RAP VGNC VGNC:30133
Macaca fascicularis IL1RAP NCBI NCBI:102133222
Others IL1RAP NCBI
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