IL10RB - interleukin 10 receptor subunit beta Gene

中文名称：白介素 10 受体亚基 β

种属: Homo sapiens

同用名: CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; IL-10RB

基因 ID: 3588 | 基因类型: protein coding

关于 IL10RB

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,266,367-33,297,221 (from NCBI)

This gene has 9 transcripts (splice variants), 210 orthologues, 11 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues.

功能概要

该基因编码的蛋白质属于细胞因子受体家族。它是活性白细胞介素 10 受体复合物所必需的辅助链。这种和 IL10RA 蛋白的共表达已被证明是 IL10 诱导的信号转导所必需的。该基因和其他三个干扰素受体基因 IFAR2、IFNAR1 和 IFNGR2 形成位于 21 号染色体上一个小区域的 II 类细胞因子受体基因簇。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

IL10RB 基因产物(4)

mRNA	Protein	Name
NM_000628.5	NP_000619.3	interleukin-10 receptor subunit beta isoform 1 precursor
NM_001405849.1	NP_001392778.1	interleukin-10 receptor subunit beta isoform 2 precursor
NM_001405850.1	NP_001392779.1	interleukin-10 receptor subunit beta isoform 3 precursor
NM_001406840.1	NP_001393769.1	interleukin-10 receptor subunit beta isoform 4 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables coreceptor activity	IDA IDA: 通过直接分析推断	16982608	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12483210	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in interleukin-10-mediated signaling pathway	IDA IDA: 通过直接分析推断	16982608	GOA
involved in positive regulation of cellular respiration	IMP IMP: 通过突变表型推断	25930096	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: 通过直接分析推断	16982608	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL10RB 蛋白结构

Tissue_fac

Interfer-bind

0
100
200
300
325 a.a.

蛋白主名

其他名称

interleukin-10 receptor subunit beta

IL-10 receptor subunit beta

重组 IL10RB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72599	IL-10R beta Protein, Human (HEK293, His)	Q08334/NP_000619.3 (M20-S220)	≥95%
HY-P74839	IL-10R beta Protein, Human (HEK293, His-hFc)	Q08334 (M20-S220)	≥95%

关联疾病

疾病名称

别名

Inflammatory Bowel Disease 25, Autosomal Recessive

Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections Syndrome	IBD25
Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive	Il10-Related Early-Onset Ibd
Il10-Related Early-Onset Inflammatory Bowel Disease	Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive
Autosomal Recessive Early-Onset Inflammatory Bowel Disease	Autosomal Recessive Early-Onset Ibd
Early-Onset Autosomal Recessive Inflammatory Bowel Disease	Bowel Disease, Inflammatory, Type 25, Autosomal Recessive

Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25	Ibd25
Inflammatory Bowel Disease 25, Autosomal Recessive

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Colitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Rubella

German Measles	Three Day Measles
Rubella Nos

Immunodeficiency 28

IMD28	Ifngr2 Deficiency
Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 28, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency
Msmd Due To Complete Ifngammar2 Deficiency	Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Immunodeficiency, Type 28, Mycobacteriosis

Folliculitis

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency	IMD35
Tyk2 Deficiency	Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis
Susceptibility To Infection Due To Tyk2 Deficiency	Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive
Hies With Atypical Mycobacteriosis, Autosomal Recessive	Autosomal Recessiv Hies With Atypical Mycobacteriosis
Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency	Autosomal Recessive Hies With Atypical Mycobacteriosis

Acute Necrotizing Encephalitis

Acute Necrotizing Encephalopathy	Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy
Ane	Acute Necrotizing Encephalopathy Type 1
Adane	Ane1
Autosomal Dominant Acute Necrotizing Encephalopathy	Iiae3
Susceptibility To Acute Necrotizing Encephalopathy	Susceptibility To Infection-Induced Acute Encephalopathy
Encephalopathy, Acute Necrotizing, Susceptibility To	Encephalitis, Acute Necrotizing

Gastrointestinal Defects And Immunodeficiency Syndrome 1

Familial Intestinal Polyatresia Syndrome	Fipa
Gastrointestinal Defects And Immunodeficiency Syndrome	Multiple Gastrointestinal Atresias
Familial Isolated Pituitary Adenoma	Intestinal Atresia, Multiple
Multiple Intestinal Atresia	GIDID1
Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency	Minat
Gidid	Meddra:10028210
Familial Isolated Pituitary Adenoma Syndrome	Intestinal Atresia Multiple
Combined Immunodeficiency-Enteropathy Spectrum	Cid-Mia/Early-Onset Ibd
Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency	Mia
Gastrointestinal Defect And Immunodeficiency Syndrome	Pituitary Adenoma Predisposition
Pituitary Adenoma, Familial Isolated

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06674	IL10RB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990776	Vimekofusp		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	IL10RB	RGD	RGD:1560373
Bos taurus	IL10RB	VGNC	VGNC:56219
Felis catus	IL10RB	VGNC	VGNC:97463
Mus musculus	IL10RB	MGD	MGI:109380

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IL10RB - interleukin 10 receptor subunit beta Gene

关于 IL10RB

功能概要

IL10RB 基因产物(4)

IL10RB 蛋白结构

重组 IL10RB 蛋白

关联疾病

直系同源

热门区域

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IL10RB - interleukin 10 receptor subunit beta Gene

关于 IL10RB

功能概要

IL10RB 基因产物(4)

IL10RB 蛋白结构

重组 IL10RB 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z