Prkdc - protein kinase, DNA-activated, catalytic subunit Gene

中文名称：蛋白激酶，DNA 激活，催化亚基

种属: Rattus norvegicus

关于 Prkdc

功能概要

预计该基因编码的蛋白具有多种功能，包括 DNA 依赖性蛋白激酶活性；酶结合活性；和核酸结合活性。参与多个过程，包括造血或淋巴器官发育；细胞衰老的负调节；和对伽马辐射反应的负调节。预测位于核仁和核质中。预计是几种细胞成分的一部分，包括 DNA 依赖性蛋白激酶-DNA 连接酶 4 复合物；蛋白质-DNA复合物；和小亚基加工体。预计活跃于核心。用于研究严重的联合免疫缺陷。该基因与免疫缺陷 26 相关的人类直向同源基因。与人类 PRKDC（蛋白激酶、DNA 激活、催化亚基）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including DNA-dependent protein kinase activity; Enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of cellular senescence; and negative regulation of response to gamma radiation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of several cellular components, including DNA-dependent protein kinase-DNA Ligase 4 complex; protein-DNA complex; and small-subunit processome. Predicted to be active in nucleus. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]