2. Gene
  3. AQP5 - aquaporin 5 Gene

AQP5 - aquaporin 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：水通道蛋白 5

种属: Homo sapiens

同用名: PPKB; AQP-5

基因 ID: 362 | 基因类型: protein coding

关于 AQP5

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,961,872-49,965,682 (from NCBI)

This gene has 2 transcripts (splice variants), 408 orthologues, 11 paralogues and is associated with 3 phenotypes. Biased expression in salivary gland (RPKM 99.1), testis (RPKM 61.9) and 1 other tissue.

功能概要

水通道蛋白 5 (AQP5) 是一种水通道蛋白。水通道蛋白是与主要内在蛋白 (MIP 或 AQP0) 相关的小型整合膜蛋白家族。水通道蛋白 5 在唾液、眼泪和肺部分泌物的产生中发挥作用。 AQP0、AQP2、AQP5 和 AQP6 密切相关，都映射到 12q13。[RefSeq 提供，2008 年 7 月]

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]

AQP5 基因产物(1)

mRNA Protein Name
NM_001651.4 NP_001642.1 aquaporin-5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18768791 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables water channel activity IDA
IDA: 通过直接分析推断
12801959 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in carbon dioxide transport IDA
IDA: 通过直接分析推断
19273840 GOA
involved in cellular hypotonic response IDA
IDA: 通过直接分析推断
26569106 GOA
involved in odontogenesis IEP
IEP: 通过表达模式推断
12522663 GOA
involved in pancreatic juice secretion IEP
IEP: 通过表达模式推断
12801959 GOA
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
18768791 GOA
involved in water transport IDA
IDA: 通过直接分析推断
18768791 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
12801959 GOA
located in cytoplasmic vesicle membrane IDA
IDA: 通过直接分析推断
26569106 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
26569106 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AQP5 蛋白结构

MIP

MIP: Major intrinsic protein (5 - 221)

  • 0
  • 100
  • 200
  • 265 a.a.
蛋白主名 其他名称

aquaporin-5

AQP5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AQP5 P55064 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra AQP5 P55064 HNRNPK Homo sapiens P61978
Validated Y2H
25416956
Intra AQP5 P55064 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra AQP5 P55064 MDFI Homo sapiens Q99750
Y2H Pooling
19060904
Intra AQP5 P55064 MDFI Homo sapiens Q99750
Y2H Array
19060904
Intra AQP5 P55064 MDFI Homo sapiens Q99750
Y2H Pooling
16189514
Intra AQP5 P55064 CREB3 Homo sapiens O43889-2
Y2H Array
31515488
Intra AQP5 P55064 ATP6V0A2 Homo sapiens Q9Y487
Anti Tag CoIP
33961781
Intra AQP5 P55064 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra AQP5 P55064 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra AQP5 P55064 AQP5 Homo sapiens P55064
X-Ray Diffraction
18768791
Intra AQP5 P55064 ATP1A2 Homo sapiens P50993
Anti Tag CoIP
33961781
Intra AQP5 P55064 AQP5 Homo sapiens P55064
GMS
18768791
Intra AQP5 P55064 ATP6V0A1 Homo sapiens Q93050
Anti Tag CoIP
33961781
Intra AQP5 P55064 CREB3 Homo sapiens O43889
Y2H
21516116
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Palmoplantar Keratoderma, Bothnian Type

PPKB

Diffuse Palmoplantar Keratoderma, Bothnian Type

Bothnian Type Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Bothnian Type

Palmoplantar Keratoderma, Nonepidermolytic
Palmoplantar Keratoderma, Nonepidermolytic

Nonepidermolytic Palmoplantar Keratoderma

NEPPK

Tylosis

Unna-Thost Syndrome

Keratoderma, Palmoplantar, Diffuse

Ppkne

Keratoderma, Nonepidermolytic Palmoplantar

Diffuse Nonepidermolytic Palmomplantar Keratoderma

Thost-Unna Syndrome

Non-Epidermolytic Palmoplantar Keratoderma

Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type

Diffuse Palmoplantar Keratoderma, Bothnian Type

Krt1-Related Diffuse Nonepidermolytic Keratoderma

Krt1-Related Diffuse Neppk

Keratoderma, Palmoplantar, Non-Epidermolytic

Nonepidermolytic Unna-Thost Disease

Non-Epidermolytic Unna-Thost Disease

Keratoderma, Palmoplantar, Nonepidermolytic

Hyperkeratosis
Dry Eye Syndrome

Dry Eye Syndromes

Dry Eye Disease

Tear Film Insufficiency

Xerophthalmia
Aplasia Of Lacrimal And Salivary Glands

ALSG

Congenital Absence Of Lacrimal Puncta And Salivary Glands

Xerostomia

Absence Of Salivary Glands

Parotid Aplasia Or Hypoplasia

Congenital Absence Of Lacrimal Puncta Or Salivary Glands

Alsg - [Aplasia Of Lacrimal Or Salivary Glands]
Pulmonary Edema
Neuromyelitis Optica

Devic Disease

Devic Syndrome

Neuromyelitis Optica Spectrum Disorder

Devic'S Disease

Devic'S Syndrome

Devic'S Neuromyelitis Optica

Nmo

Nmo Spectrum Disorder

Neuromyelitis Optica Spectrum Disorders

Devic Neuromyelitis Optica

Optic-Spinal Ms

Opticospinal Ms

Nmosd

Opticospinal Multiple Sclerosis

Devic

Ophthalmoneuromyelitis

Optic Neuromyelitis

Optic Neuroencephalomyelopathy

Nmo - [Neuromyelitis Optica]

Optic Neuritis With Demyelination
Brain Edema

Cerebral Edema

Intracranial Swelling

Wet Brain
Sjogren Syndrome

Sicca Syndrome

Sjogren'S Syndrome

Sjögren Syndrome

Sjogren-Gougerot Syndrome

Keratoconjunctivitis Sicca

Sjögren'S Syndrome

Xerodermosteosis

Dacryosialoadenopathia Atrophicans

Gougerot-Houwer-Sjogren Syndrome

Gougerot-Sjogren Syndrome

Keratoconjunctivitis Sicca-Xerostomia

Secreto-Inhibitor-Xerodermostenosis

Primary Sjogren Syndrome

Primary Sjogren-Gougerot Syndrome

Sjogrens Syndrome Primary

Sjogrens Syndrome

Dry Eye Syndromes
Dacryoadenitis

Dacryocystitis
Accommodative Spasm

Spasm Of Accommodation

Cyclospasm

Ciliary Muscle Spasm

Ciliary Body Spasm
Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases
Sialolithiasis

Sialolith

Stone Of Salivary Gland Or Duct

Salivary Gland Calculi

Salivary Gland Stone

Calculus Of Salivary Gland Or Duct

Calculus Of Salivary Gland

Salivary Calculus

Salivary Gland Calculus

Salivary Stone

Salivary Duct Calculi

Sialodocholithiasis
Acrokeratoderma, Hereditary Papulotranslucent

Hereditary Papulotranslucent Acrokeratoderma
Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea
Sialadenitis

Sialoadenitis

Adenitis, Salivary Gland

Salivary Gland Inflammation

Salivary Gland Adenitis

Sialitis

Inflammation Of Salivary Gland

Inflammation Of Salivary Duct Or Gland

Salivary Glandular Adenitis

Sialoangiitis

Sialoangitis

Sialodochitis
Keratoconjunctivitis Sicca

Kcs

Dry Eye Syndromes

Keratitis Sicca

Xerophthalmia
Diffuse Pulmonary Fibrosis
Autoimmune Disease Of Exocrine System
Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus

Diabetes Insipidus, Nephrogenic

Diabetes Insipidus Nephrogenic

Congenital Nephrogenic Diabetes Insipidus

Adh Resistant Diabetes Insipidus

Diabetes Insipidus Nephrogenic X-Linked

Diabetes Insipidus Nephrogenic Type 1

Adh-Resistant Diabetes Insipidus

Diabetes Insipidus Renalis

Ndi

Renal Diabetes Insipidus

Familial Nephrogenic Diabetes

Antidiuretic-Hormone-Resistant Diabetes Insipidus

Adiuretin-Resistant Diabetes Insipidus

Ndi - [Nephrogenic Diabetes Insipidus]

Diabetes Tenuifluus

Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus

Hereditary Nephrogenic Diabetes Insipidus

Familial Nephrogenic Diabetes Insipidus

Primary Nephrogenic Diabetes Insipidus
Presbyopia

Subnormal Accommodation

Accommodation Insufficiency Of Old Age
Xerophthalmia

Conjunctival Xerosis
Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS
Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00877 AQP5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AQP5 VGNC VGNC:57418
Mus musculus AQP5 MGD MGI:106215
Felis catus AQP5 VGNC VGNC:83497
Rattus norvegicus AQP5 RGD RGD:2144
Macaca mulatta AQP5 VGNC VGNC:108321
Bos taurus AQP5 VGNC VGNC:26048
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