ATP6V0A1 - ATPase H+ transporting V0 subunit a1 Gene

中文名称：ATPase H+ 转运 V0 亚基 a1

种属: Homo sapiens

同用名: a1; Stv1; VPP1; Vph1; ATP6N1; DEE104; NEDEBA; ATP6N1A

关于 ATP6V0A1

功能概要

该基因编码液泡 ATP 酶 (V-ATPase) 的一个组分，这是一种介导真核细胞内细胞器酸化的多亚基酶。 V-ATPase 依赖性细胞器酸化对于蛋白质分选、酶原激活、受体介导的内吞作用和突触小泡质子梯度生成等细胞内过程是必需的。 V-ATPase 由胞质 V1 结构域和跨膜 V0 结构域组成。 V1 结构域由三个 A 和三个 B 亚基、两个 G 亚基以及 C、D、E、F 和 H 亚基组成。 V1 域包含 ATP 催化位点。 V0 结构域由五个不同的亚基组成：a、c、c'、c" 和 d。许多 V1 和 V0 亚基蛋白的其他同种型由多个基因或选择性剪接的转录变体编码。该基因编码以下三种之一 A 亚基蛋白和编码的蛋白与网格蛋白包被的囊泡相关。已发现该基因编码不同亚型的三种转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]