Cenpe - centromere protein E Gene

中文名称：着丝粒蛋白E

种属: Rattus norvegicus

关于 Cenpe

功能概要

预计该基因编码的蛋白可启动多种功能，包括动粒结合活动；微管结合活性；和加端定向微管运动活动。预计参与多个过程，包括着丝粒组装；有丝分裂姐妹染色单体分离；和有丝分裂中期/后期转变的调节。预计在女性减数分裂 I 中涉及的蛋白质稳定性和纺锤体装配的调节上游或调节内起作用。预计位于几种细胞成分中，包括着丝粒；中体;和主轴。预计是外着丝粒的一部分。预计在微管中活跃。该基因的人类直系同源物与原发性常染色体隐性遗传性小头畸形 13 相关。与人类 CENPE（着丝粒蛋白 E）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including kinetochore binding activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in several processes, including kinetochore assembly; mitotic sister chromatid segregation; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Predicted to be located in several cellular components, including kinetochore; midbody; and spindle. Predicted to be part of outer kinetochore. Predicted to be active in microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Apr 2022]