2. Gene
  3. Carm1 - coactivator-associated arginine methyltransferase 1 Gene

Carm1 - coactivator-associated arginine methyltransferase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：共激活因子相关精氨酸甲基转移酶 1

种属: Rattus norvegicus

同用名: Prmt4

基因 ID: 363026 | 基因类型: protein coding

关于 Carm1

Primary_assembly 8: 20,097,254-20,147,689 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 218 orthologues, 10 paralogues and is associated with 8 phenotypes. Biased expression in Muscle (RPKM 111.1), Heart (RPKM 11.5) and 9 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能，包括赖氨酸乙酰化组蛋白结合活性；核受体共激活因子活性；和蛋白质-精氨酸 N-甲基转移酶活性。参与多个过程，包括树突发育的负调控； mRNA结合活性的调节；和对 cAMP 的反应。位于细胞质和细胞核中。哮喘的生物标志物；肝细胞腺瘤；和肝细胞癌。与人类 CARM1（共激活剂相关的精氨酸甲基转移酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including negative regulation of dendrite development; regulation of mRNA binding activity; and response to cAMP. Located in cytoplasm and nucleus. Biomarker of asthma; hepatocellular adenoma; and hepatocellular carcinoma. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Carm1 基因产物(2)

mRNA Protein Name
NM_001034088.3 NP_001029260.1 histone-arginine methyltransferase CARM1 isoform b
NM_001030041.4 NP_001025212.1 histone-arginine methyltransferase CARM1 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16330542 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of dendrite development IMP
IMP: 通过突变表型推断
22736542 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16508003 RGD
involved in response to cAMP IDA
IDA: 通过直接分析推断
16330542 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Carm1 蛋白结构

CARM1

CARM1: pfam11531 (34 - 138)

SmtA

SmtA: COG0500 (184 - 394)

AdoMet_MTases

AdoMet_MTases: cd02440 (188 - 283)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 608 a.a.
蛋白主名 其他名称

histone-arginine methyltransferase CARM1

protein arginine N-methyltransferase 4

相关产品

Pre-clinical Phase
生物活性分子 (25)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111109 EZM 2302 Inhibitor 99.59% 否
HY-114965 TP-064 Inhibitor 99.61% 否
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% 否
HY-100565 SGC2085 Inhibitor 99.46% 否
HY-12759 CARM1-IN-1 Inhibitor ≥95.0% 否
HY-15214A CARM1-IN-3 dihydrochloride Inhibitor 98.77% 否
HY-156152A CARM1 degrader-1 hydrochloride Degrader / 否
HY-12759A CARM1-IN-1 hydrochloride Inhibitor 95.13% 否
HY-15214 CARM1-IN-3 Inhibitor 98.90% 否
HY-157388 CARM1/HDAC2-IN-1 Inhibitor / 否
HY-100855 DC_C66 Inhibitor / 否
HY-100565A SGC2085 hydrochloride Inhibitor / 否
HY-110137A Furamidine Inhibitor / 否
HY-136809 PRMT6-IN-2 / 否
HY-156152 CARM1 degrader-1 Inhibitor / 否
HY-156153 CARM1 degrader-2 Inhibitor / 否
HY-158157 ZL-28-6 Inhibitor / 否
HY-158158 CARM1-IN-5 Inhibitor / 否
HY-161334 CARM1-IN-4 / 否
HY-163561 CARM1-IN-6 Inhibitor / 否
HY-RS01926 CARM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01927 Carm1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01928 Carm1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117927 EPZ0025654 Inhibitor / 否
HY-W013500 (1-Nitroethene-1,2-diyl)dibenzene / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Carm1 NCBI NCBI:10498
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