1. Gene
  2. ITGAE - integrin subunit alpha E Gene

ITGAE - integrin subunit alpha E Gene

中文名称:整合素亚基 alpha E

种属: Homo sapiens

同用名: CD103; HUMINAE

基因 ID: 3682 | 基因类型: protein coding

关于 ITGAE

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,714,628-3,801,188 (from NCBI)

This gene has 9 transcripts (splice variants), 164 orthologues and 17 paralogues. Ubiquitous expression in bone marrow (RPKM 3.1), small intestine (RPKM 2.6) and 25 other tissues.

功能概要

整联蛋白是由α链和β链组成的异二聚体整合膜蛋白。该基因编码含有 I 结构域的 α 整合素,该整合素在细胞外结构域中进行翻译后切割,产生二硫键连接的重链和轻链。结合 β 7 整合素,该蛋白质形成 E-钙粘蛋白结合整合素,称为人粘膜淋巴细胞-1 抗原。这种蛋白质优先在人肠上皮内淋巴细胞 (IEL) 中表达,除了粘附作用外,它还可以作为 IEL 激活的辅助分子。[RefSeq 提供,2008 年 7 月]

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha Integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 Integrin, this protein forms the E-cadherin binding Integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

ITGAE 基因产物(1)

mRNA Protein Name
NM_002208.5 NP_002199.3 integrin alpha-E precursor

ITGAE 蛋白结构

VWA

VWA: von Willebrand factor type A domain (203 - 376)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (676 - 1082)

Integrin_alpha

Integrin_alpha: Integrin alpha cytoplasmic region (1148 - 1159)

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  • 1179 a.a.
蛋白主名 其他名称

integrin alpha-E

HML-1 antigen

ITGAE 抗体

目录号 产品名 应用 反应物种
HY-P81498 CD103 Antibody (YA1243) IHC-P Human
HY-P83306 Integrin alpha E Antibody (YA3051) IHC-P Human

关联疾病

疾病名称 别名
Enteropathy-Associated T-Cell Lymphoma

Intestinal T-Cell Lymphoma

Eatcl

High-Grade Pleomorphic Peripheral T-Cell Lymphoma

Eatl

Ettl

Enteropathy-Type T-Cell Lymphoma

Enteropathy Type Intestinal T-Cell Lymphoma

Mycosis Fungoides

Mycosis Fungoides Lymphoma

Alibert-Bazin Syndrome

Granuloma Fungoides

Classic Mycosis Fungoides

Mycosis Fungoides, Alibert-Bazin Type

Hairy Cell Leukemia

Hcl-V

Hairy Cell Leukemia Variant

Hairy Cell Leukaemia Variant

Hcl

Leukemic Reticuloendotheliosis

Leukemic Reticuloendotheliosis Variant

Prolymphocytic Variant Of Hcl

Prolymphocytic Variant Of Hairy Cell Leukemia

Leukemia Hairy Cell

Leukemia, Hairy Cell

Leukaemic Reticuloendotheliosis

Lre - [Leukemic Reticuloendotheliosis]

Hairy-Cell Leukaemia, Nos

Hcl - [Hairy Cell Leukaemia]

Hairy-Cell Leukaemia Without Mention Of Remission

Spleen Cancer

Spleen Neoplasm

Splenic Neoplasm

Splenic Neoplasms

Malignant Splenic Tumor

Malignant Tumour Of Spleen

Tumor Of Spleen

Malignant Neoplasm Of Spleen

Splenic Marginal Zone Lymphoma

Smzl

Splenic Marginal Zone B-Cell Lymphoma

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Cutaneous T-Cell Lymphoma

Cutaneous T Cell Lymphoma

Lymphoma, T-Cell, Cutaneous

Ctcl

Lymphoma T-Cell Cutaneous

B-Cell Prolymphocytic Leukemia

B Cell Prolymphocytic Leukemia

Prolymphocytic Leukemia, B-Cell Type

B-Pll

Doid:0081041

Leukemia, Prolymphocytic, B-Cell

Pll- [Prolymphocytic Leukaemia]

Prolymphocytic Leukaemia

Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Cystinosis

Cystine Storage Disease

Cystine Diathesis

Cystine Disease

Cystinoses

Protein Defect Of Cystin Transport

Cystin Transport, Protein Defect Of

Nephropathic Cystinosis

Protein Defect Of Cystine Transport

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Mesenteric Lymphadenitis

Mesenteric Adenitis

Splenic Disease

Splenic Diseases

Dyssplenism

Spleen Disease

Abnormality Of The Spleen

Spleen Diseases

Sarcoid Meningitis

Meningitis In Sarcoidosis

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Autoimmune Disease Of Gastrointestinal Tract
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ITGAE VGNC VGNC:42131
Bos taurus ITGAE VGNC VGNC:30321
Felis catus ITGAE VGNC VGNC:67847
Mus musculus ITGAE MGD MGI:1298377
Rattus norvegicus ITGAE RGD RGD:621644