ITGB6 - integrin subunit beta 6 Gene

中文名称：整合素亚基β6

种属: Homo sapiens

同用名: AI1H

基因 ID: 3694 | 基因类型: protein coding

关于 ITGB6

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:160,099,671-160,200,272 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues, 8 paralogues and is associated with 4 phenotypes. Biased expression in lung (RPKM 25.8), urinary bladder (RPKM 17.2) and 12 other tissues.

功能概要

该基因编码的蛋白质是整合素超家族的成员。该家族的成员是粘附受体，在从细胞外基质到细胞的信号传递中发挥作用。整联蛋白是由α链和β链组成的异二聚体整合膜蛋白。编码的蛋白质与 alpha v 链形成二聚体，这种异二聚体可以与纤连蛋白和转化生长因子 beta 1 等配体结合。交替剪接会产生多个转录变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a protein that is a member of the Integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ITGB6 基因产物(7)

mRNA	Protein	Name
NM_000888.5	NP_000879.2	integrin beta-6 isoform a precursor
NM_001282353.2	NP_001269282.1	integrin beta-6 isoform a precursor
NM_001282354.2	NP_001269283.1	integrin beta-6 isoform b precursor
NM_001282355.2	NP_001269284.1	integrin beta-6 isoform c precursor
NM_001282388.2	NP_001269317.1	integrin beta-6 isoform d
NM_001282389.2	NP_001269318.1	integrin beta-6 isoform e
NM_001282390.2	NP_001269319.1	integrin beta-6 isoform f

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17158881	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell adhesion mediated by integrin	IDA IDA: 通过直接分析推断	17158881	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in focal adhesion	IDA IDA: 通过直接分析推断	17158881	GOA
part of integrin alphav-beta6 complex	IDA IDA: 通过直接分析推断	22278742	GOA
part of integrin alphav-beta6 complex	IPI IPI: 通过物理相互作用推断	25383667	GOA
part of receptor complex	IDA IDA: 通过直接分析推断	23382219	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ITGB6 蛋白结构

Integrin_beta

EGF_2

Integrin_B_tail

Integrin_b_cyt

0
200
400
600
788 a.a.

蛋白主名

其他名称

integrin beta-6

integrin, beta 6

重组 ITGB6 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73867	Integrin alpha V beta 6 Protein, Human (HEK293, Flag-His)	P06756-1 (F31-V992)&P18564-1 (G22-N707)	≥95%
HY-P77721	Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P18564-1 (G22-N707)	≥95%
HY-P700768	ITGB6 Protein, Human (HEK293, His)	P18564-1 (G22-N707)	≥95%

关联疾病

疾病名称

别名

Amelogenesis Imperfecta, Type Ih

AI1H	Amelogenesis Imperfecta Type 1h
Amelogenesis Imperfecta Type Ih	Amelogenesis Imperfecta 1h
Amelogenesis Imperfecta, Type 1h

Alopecia-Mental Retardation Syndrome 1

APMR1	Alopecia-Intellectual Disability Syndrome 1
Amr Syndrome	Alopecia-Intellectual Disability Syndrome
Amr Syndrome 1	Alopecia With Severe Intellectual Deficit
Apmr	Alopecia Intellectual Disbility Syndrome 1
Perniola-Krajewska-Carnevale Syndrome	Alopecia - Intellectual Disability Syndrome
Alopecia With Mental Retardation Syndrome 1	Perniola Krajewska Carnevale Syndrome

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Hypoplastic Amelogenesis Imperfecta

Amelogenesis Imperfecta Type 1	Amelogenesis Imperfecta, Hypoplastic Type
Amelogenesis Imperfecta Local Hypoplastic Form

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Mouth Disease

Mouth Diseases

Mouth Disorders

Pulmonary Emphysema

Premature Ovarian Failure 19

POF19	Primary Ovarian Insufficiency 19
Poi19	Ovarian Failure, Premature, Type 19

Bullous Keratopathy

Bk - [Bullous Keratopathy]

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Cholangiolocellular Carcinoma

Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia

Junctional Epidermolysis Bullosa With Pyloric Atresia	Carmi Syndrome
Epidermolysis Bullosa, Junctional, With Pyloric Atresia	Jeb-Pa
JEB5B	Epidermolysis Bullosa Junctionalis With Pyloric Atresia
Aplasia Cutis Congenita With Gastrointestinal Atresia	Epidermolysis Bullosa, Junctional, With Pyloric Atresia And Aplasia Cutis Congenita
Eb-Pa-Acc	Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome
Jeb With Pyloric Atresia	Epidermolysis Bullosa Letalis, With Pyloric Atresia
Pa-Jeb	Epidermolysis Bullosa With Pyloric Atresia

Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional	Jeb
Epidermolysis Bullosa Atrophicans	Congenital Junctional Epidermolysis Bullosa
Epidermolysis Bullosa Junctional	Junctional Eb - [Epidermolysis Bullosa]
Jeb - [Junctional Epidermolysis Bullosa]	Lucidolytic Epidermolysis Bullosa

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06970	ITGB6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ITGB6	RGD	RGD:1303119
Bos taurus	ITGB6	VGNC	VGNC:30331
Felis catus	ITGB6	VGNC	VGNC:67855
Macaca mulatta	ITGB6	VGNC	VGNC:73789
Canis familiaris	ITGB6	VGNC	VGNC:42141
Mus musculus	ITGB6	MGD	MGI:96615
Others	ITGB6	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ITGB6 - integrin subunit beta 6 Gene

关于 ITGB6

功能概要

ITGB6 基因产物(7)

ITGB6 蛋白结构

重组 ITGB6 蛋白

关联疾病

直系同源

热门区域

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ITGB6 - integrin subunit beta 6 Gene

关于 ITGB6

功能概要

ITGB6 基因产物(7)

ITGB6 蛋白结构

重组 ITGB6 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z