1. Gene
  2. ITGB8 - integrin subunit beta 8 Gene

ITGB8 - integrin subunit beta 8 Gene

中文名称:整合素亚基β8

种属: Homo sapiens

基因 ID: 3696 | 基因类型: protein coding

关于 ITGB8

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:20,329,766-20,415,754 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues and 8 paralogues. Broad expression in kidney (RPKM 12.1), brain (RPKM 11.6) and 19 other tissues.

功能概要

该基因是整合素 β 链家族的成员,编码具有 VWFA 结构域和四个富含半胱氨酸的重复序列的单程 I 型膜蛋白。这种蛋白质与 α 亚基非共价结合形成异二聚体整合素复合物。一般而言,整合素复合物介导细胞与细胞和细胞与细胞外基质的相互作用,并且该复合物在人气道上皮细胞增殖中发挥作用。已经描述了编码不同蛋白质同种型的可变剪接变体;然而,并非所有变体都得到了充分表征。[RefSeq 提供,2008 年 7 月]

This gene is a member of the Integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric Integrin complex. In general, Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

ITGB8 基因产物(1)

mRNA Protein Name
NM_002214.3 NP_002205.1 integrin beta-8 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables extracellular matrix protein binding IDA
IDA: 通过直接分析推断
7525578 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cartilage development IMP
IMP: 通过突变表型推断
24312400 GOA
NOT involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
7525578 GOA
involved in integrin-mediated signaling pathway IDA
IDA: 通过直接分析推断
11970960 GOA
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
24312400 GOA
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
25801897 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
24312400 GOA
involved in vasculogenesis IMP
IMP: 通过突变表型推断
12050137 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
1918072 GOA
part of integrin alphav-beta8 complex IDA
IDA: 通过直接分析推断
1918072 GOA
part of integrin alphav-beta8 complex IPI
IPI: 通过物理相互作用推断
30061598 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ITGB8 蛋白结构

Integrin_beta

Integrin_beta: Integrin beta chain VWA domain (54 - 469)

EGF_2

EGF_2: EGF-like domain (553 - 583)

  • 0
  • 200
  • 400
  • 600
  • 769 a.a.
蛋白主名 其他名称

integrin beta-8

重组 ITGB8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72535 Integrin alpha V beta 8 Protein, Human (HEK293, His) P06756-1 (F31-V992)&P26012-1 (E43-R684) ≥95%
HY-P73865 Integrin alpha V beta 8 Protein, Human (HEK293, His, solution) P06756-1 (F31-V992)&P26012-1 (E43-R684) ≥95%
HY-P77722 Integrin alpha V beta 8 Protein, Human (HEK293, His-Avi) P06756-1 (F31-V992)&P26012-1 (E43-R684) ≥95%

关联疾病

疾病名称 别名
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ITGB8 VGNC VGNC:73791
Felis catus ITGB8 VGNC VGNC:67857
Mus musculus ITGB8 MGD MGI:1338035
Rattus norvegicus ITGB8 RGD RGD:1311374
Bos taurus ITGB8 VGNC VGNC:30333
Canis familiaris ITGB8 VGNC VGNC:42143
Others ITGB8 NCBI
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