KCNN2 - potassium calcium-activated channel subfamily N member 2 Gene

中文名称：钾钙激活通道亚家族 N 成员 2

种属: Homo sapiens

同用名: SK2; hSK2; DYT34; SKCA2; KCa2.2; NEDMAB; SKCa 2

关于 KCNN2

功能概要

脊椎动物神经元的动作电位之后是可能持续数秒的后超极化 (AHP) ，并且可能对神经元的放电模式产生深远影响。 AHP 的每个组成部分在动力学上都是不同的，并且由不同的钙激活钾通道介导。由该基因编码的蛋白质在膜超极化之前被激活，并被认为通过促进突触 AHP 的缓慢成分来调节神经元兴奋性。该基因是钾通道基因 KCNN 家族的成员。编码的蛋白质是一种完整的膜蛋白，与其他三个钙调蛋白结合亚基形成电压依赖性钙激活通道。该基因的交替剪接导致多个转录变体。[RefSeq 提供，2013 年 5 月]

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of Potassium Channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three Other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]