KLRB1 - killer cell lectin like receptor B1 Gene

中文名称：杀伤细胞凝集素样受体 B1

种属: Homo sapiens

同用名: NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A

关于 KLRB1

功能概要

自然杀伤 (NK) 细胞是介导细胞毒性并在免疫刺激后分泌细胞因子的淋巴细胞。 C 型凝集素超家族的几个基因，包括啮齿动物 NKRP1 糖蛋白家族，由 NK 细胞表达并可能参与 NK 细胞功能的调节。 KLRB1 蛋白包含一个具有 C 型凝集素特征的多个基序的胞外结构域、一个跨膜结构域和一个细胞质结构域。 KLRB1 蛋白被归类为 II 型膜蛋白，因为它具有外部 C 末端。[RefSeq 提供，2008 年 7 月]

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]