1. Gene
  2. ARG2 - arginase 2 Gene

ARG2 - arginase 2 Gene

中文名称:精氨酸酶 2

种属: Homo sapiens

基因 ID: 384 | 基因类型: protein coding

关于 ARG2

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:67,619,920-67,651,708 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 94.3), prostate (RPKM 64.4) and 23 other tissues.

功能概要

精氨酸酶催化精氨酸水解成鸟氨酸和尿素。至少存在两种哺乳动物精氨酸酶同种型 (I 型和 II 型) ,它们在组织分布、亚细胞定位、免疫交叉反应性和生理功能方面有所不同。由该基因编码的 II 型亚型位于线粒体中,并在肝外组织,尤其是肾脏中表达。这种亚型的生理作用知之甚少;它被认为在一氧化氮和多胺代谢中发挥作用。已经描述了使用替代聚腺苷酸化位点产生的 II 型基因的转录变体。[RefSeq 提供,2008 年 7 月]

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian Arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

ARG2 基因产物(1)

mRNA Protein Name
NM_001172.4 NP_001163.1 arginase-2, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables arginase activity IMP
IMP: 通过突变表型推断
16128822 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
28614294 GOA
involved in positive regulation of cellular senescence IDA
IDA: 通过直接分析推断
22928666 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ARG2 蛋白结构

Arginase

Arginase: Arginase family (25 - 321)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

arginase-2, mitochondrial

L-arginine amidinohydrolase

ARG2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARG2 P78540 FOXD4L6 Homo sapiens Q3SYB3
Validated Y2H
32814053
种属内
ARG2 P78540 FOXD4L6 Homo sapiens Q3SYB3
Y2H Array
32814053
种属内
ARG2 P78540 FOXD4L6 Homo sapiens Q3SYB3
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ARG2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7603 Arginase-2/ARG2 Protein, Human (His) P78540 (H24-G330) ≥95%

关联疾病

疾病名称 别名
Argininemia

Hyperargininemia

Arginase Deficiency

Arg1 Deficiency

Arginase-1 Deficiency

Deficiency Of Canavanase

Arginase Deficiency Disease

ARGIN

Ovarian Wilms' Cancer

Ovarian Wilms' Tumor

Urea Cycle Disorder

Urea Cycle Disorders

Urea Cycle Disorders, Inborn

Disorder Of Metabolism Of Ornithine, Citrulline, Argininosuccinic Acid, Arginine And Ammonia

Disorder Of Urea Cycle Metabolism

Urea Cycle Defect

Ucd

Disorder Of The Urea Cycle Metabolism

Disorder Of Urea Cycle

Disorders Of Metabolism Of Ornithine, Citrulline, Argininosuccinic Acid, Arginine And Ammonia

Ammonia Metabolic Disorder

Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event

Argininosuccinic Aciduria

Argininosuccinate Lyase Deficiency

Asl Deficiency

Argininosuccinic Acid Lyase Deficiency

Argininosuccinase Deficiency

Argininosuccinic Acidemia

Arginosuccinase Deficiency

Asa Deficiency

Argininosuccinicaciduria

Asauria

Deficiency Of Argininosuccinate Lyase

Asld

Arginino Succinase Deficiency

Argininosuccinate Acidemia

Inborn Error Of Urea Synthesis, Arginino Succinic Type

Urea Cycle Disorder, Arginino Succinase Type

Argininosuccinyl-Coa Lyase Deficiency

Asa

Argininosuccinatelyase Deficiency

ARGINSA

Aciduria Argininosuccinic

Citrullinemia

Argininosuccinic Acidaemia

Metabolic Disorder Of Arginosuccinic Acid

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Priapism

Mentulagra

Priapism, Familial Idiopathic

Familial Idiopathic Priapism

Pathologic Erection

Painful Erection

Citrullinemia, Classic

Citrullinemia

Classic Citrullinemia

Argininosuccinate Synthetase Deficiency

Ass Deficiency

Citrullinemia Type I

CTLN1

Citrullinuria

Citrullinemia, Type I

Argininosuccinic Acid Synthetase Deficiency

Ctnl1

Citrullinemia 1

Deficiency Of Citrulline-Aspartate Ligase

Cit

Argininosuccinate Synthase Deficiency

Argininosuccinic Acid Synthase Deficiency

Citrullinemia Type 1

Citrullinemia Classical

Penile Disease

Penile Diseases

Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder

Spastic Diplegia

Diplegic Infantile Cerebral Palsy

Little'S Disease

Cerebral Palsy

Cerebral Spastic Infantile Paralysis

Infantile Diplegic Cerebral Palsy

Infantile Spastic Cerebral Palsy

Littles Disease

Spastic Cerebral Palsy

Visceral Leishmaniasis

Kala-Azar

Leishmaniasis, Visceral

Infection By Visceral Leishmaniasis

Leishmaniasis Visceral

Sahib Disease

Ponos

Burdwan Fever

Mard El Bicha

Sirkari Disease

Indian Visceral Leishmaniasis

Dumdum Fever

Visceral Leishmaniasis Due To Leishmania Donovani

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Myopathy

Muscular Diseases

Myopathies

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ARG2 VGNC VGNC:38042
Macaca mulatta ARG2 VGNC VGNC:70005
Felis catus ARG2 VGNC VGNC:68069
Mus musculus ARG2 MGD MGI:1330806
Bos taurus ARG2 VGNC VGNC:26071
Rattus norvegicus ARG2 RGD RGD:2151
Others ARG2 NCBI