NPSR1 - neuropeptide S receptor 1 Gene

中文名称：神经肽 S 受体 1

种属: Homo sapiens

同用名: GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154

基因 ID: 387129 | 基因类型: protein coding

关于 NPSR1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:34,658,218-34,878,332 (from NCBI)

This gene has 9 transcripts (splice variants), 382 orthologues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

该基因编码 G 蛋白偶联受体的加压素/催产素亚家族成员。编码的膜蛋白充当神经肽 S 的受体，并通过其信号传导影响各种细胞过程。该基因在呼吸道上皮纤毛细胞和支气管平滑肌细胞中的表达增加与哮喘有关。该基因的多态性也与哮喘易感性、恐慌症、炎症性肠病和类风湿性关节炎有关。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

NPSR1 基因产物(5)

mRNA	Protein	Name
NM_001300933.2	NP_001287862.1	neuropeptide S receptor isoform B short
NM_001300934.2	NP_001287863.1	neuropeptide S receptor isoform F
NM_001300935.2	NP_001287864.1	neuropeptide S receptor isoform G
NM_207172.2	NP_997055.1	neuropeptide S receptor isoform A
NM_207173.2	NP_997056.1	neuropeptide S receptor isoform B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables neuropeptide receptor activity	IDA IDA: 通过直接分析推断	16790440	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in neuropeptide signaling pathway	IDA IDA: 通过直接分析推断	15947423	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: 通过直接分析推断	16790440	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15947423	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15947423	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NPSR1 蛋白结构

7tm_1

0
100
200
300
371 a.a.

蛋白主名

其他名称

neuropeptide S receptor

G-protein coupled receptor 154

关联疾病

疾病名称

别名

Asthma-Related Traits 2

Asthma-Related Traits, Susceptibility To, 2	ASRT2
Asthma, Susceptibility To, 2	Asthma 2
Asthma-Related Traits, Susceptibility To, Type 2

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09503	NPSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NPSR1	VGNC	VGNC:32216
Macaca mulatta	NPSR1	VGNC	VGNC:81730
Rattus norvegicus	NPSR1	RGD	RGD:1564154
Felis catus	NPSR1	VGNC	VGNC:63875
Mus musculus	NPSR1	MGD	MGI:2441738
Canis familiaris	NPSR1	VGNC	VGNC:54789

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NPSR1 - neuropeptide S receptor 1 Gene

关于 NPSR1

功能概要

NPSR1 基因产物(5)

NPSR1 蛋白结构

关联疾病

直系同源

热门区域

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NPSR1 - neuropeptide S receptor 1 Gene

关于 NPSR1

功能概要

NPSR1 基因产物(5)

NPSR1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z