2. Gene
  3. MUC21 - mucin 21, cell surface associated Gene

MUC21 - mucin 21, cell surface associated Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：粘蛋白 21，细胞表面相关

种属: Homo sapiens

同用名: MUC-21; KMQK697; C6orf205

基因 ID: 394263 | 基因类型: protein coding

关于 MUC21

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,983,718-30,989,903 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele and 29 orthologues. Restricted expression toward esophagus (RPKM 485.6).

功能概要

该基因编码一种大的膜结合糖蛋白，它是粘蛋白家族的一员。粘蛋白是 O-糖基化蛋白质，在上皮表面形成保护性粘液屏障方面发挥重要作用。这些蛋白质还在细胞内信号传导中发挥作用。编码的蛋白质包含一个 N 端信号序列、一个细胞外粘蛋白结构域、一个干结构域、一个跨膜结构域和一个 C 端胞质尾结构域。粘蛋白结构域包含 O-糖基化位点，并且具有多态性，同工型包含数量不等的富含脯氨酸、苏氨酸和丝氨酸的串联重复序列，每个重复序列包含 15 个氨基酸。该基因的异常表达与肺腺癌有关。[RefSeq 提供，2017 年 5 月]

This gene encodes a large membrane-bound glycoprotein which is a member of the Mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular Mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The Mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 Amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017]

MUC21 基因产物(3)

mRNA Protein Name
NM_001010909.5 NP_001010909.2 mucin-21 isoform 1 precursor
NM_001322370.2 NP_001309299.1 mucin-21 isoform 2 precursor
NM_001322371.2 NP_001309300.2 mucin-21 isoform 3 precursor

MUC21 蛋白结构

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (20 - 72)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (63 - 93)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (76 - 127)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (91 - 143)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (121 - 173)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (135 - 189)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (167 - 223)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (212 - 264)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (257 - 315)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (304 - 352)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (315 - 369)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (346 - 393)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (361 - 412)

Epiglycanin_TR

Epiglycanin_TR: Tandem-repeating region of mucin, epiglycanin-like (390 - 459)

Epiglycanin_C

Epiglycanin_C: Mucin, catalytic, TM and cytoplasmic tail region (461 - 565)

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  • 566 a.a.
蛋白主名 其他名称

mucin-21

epiglycanin

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08840 MUC21 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MUC21 MGD MGI:3779983
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