LGALS9 - galectin 9 Gene

中文名称：半乳糖凝集素 9

种属: Homo sapiens

同用名: HUAT; LGALS9A

基因 ID: 3965 | 基因类型: protein coding

关于 LGALS9

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:27,631,188-27,649,560 (from NCBI)

This gene has 16 transcripts (splice variants), 353 orthologues and 16 paralogues. Broad expression in spleen (RPKM 33.5), stomach (RPKM 28.4) and 23 other tissues.

功能概要

半乳糖凝集素是β-半乳糖苷结合蛋白家族，参与调节细胞-细胞和细胞-基质相互作用。该基因编码的蛋白质是一种 S 型凝集素。它在霍奇金病组织中过度表达，可能参与 H&RS 细胞与其周围细胞之间的相互作用，因此可能在该疾病和/或其相关免疫缺陷的发病机制中发挥作用。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

LGALS9 基因产物(3)

mRNA	Protein	Name
NM_001330163.2	NP_001317092.1	galectin-9 isoform 3
NM_002308.4	NP_002299.2	galectin-9 isoform short
NM_009587.3	NP_033665.1	galectin-9 isoform long

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables carbohydrate binding	IDA IDA: 通过直接分析推断	18977853	GOA
enables disaccharide binding	IMP IMP: 通过突变表型推断	16116184	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	21670307	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	16116184	GOA
involved in cellular response to type II interferon	IDA IDA: 通过直接分析推断	23817958	GOA
involved in cellular response to virus	IMP IMP: 通过突变表型推断	25754930	GOA
involved in female pregnancy	IDA IDA: 通过直接分析推断	23242525	GOA
involved in inflammatory response	IDA IDA: 通过直接分析推断	23817958	GOA
involved in maternal process involved in female pregnancy	IDA IDA: 通过直接分析推断	25578313	GOA
NOT involved in mature conventional dendritic cell differentiation	IMP IMP: 通过突变表型推断	25754930	GOA
involved in natural killer cell tolerance induction	IMP IMP: 通过突变表型推断	25578313	GOA
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: 通过直接分析推断	20209097	GOA
involved in negative regulation of activated T cell proliferation	IMP IMP: 通过突变表型推断	23817958	GOA
involved in negative regulation of chemokine production	IMP IMP: 通过突变表型推断	25754930	GOA
involved in negative regulation of gene expression	IDA IDA: 通过直接分析推断	23408620	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	25578313	GOA
involved in negative regulation of mast cell degranulation	IMP IMP: 通过突变表型推断	24465902	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	23408620	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	25578313	GOA
involved in negative regulation of type II interferon production	IDA IDA: 通过直接分析推断	23408620	GOA
involved in p38MAPK cascade	IDA IDA: 通过直接分析推断	16116184	GOA
involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	IDA IDA: 通过直接分析推断	20209097	GOA
involved in positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: 通过直接分析推断	16116184	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	24465902	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	25754930	GOA
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA IDA: 通过直接分析推断	16116184	GOA
involved in positive regulation of activated T cell autonomous cell death	IDA IDA: 通过直接分析推断	20209097	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: 通过突变表型推断	24465902	GOA
involved in positive regulation of dendritic cell apoptotic process	IDA IDA: 通过直接分析推断	16116184	GOA
involved in positive regulation of dendritic cell chemotaxis	IMP IMP: 通过突变表型推断	25754930	GOA
involved in positive regulation of dendritic cell differentiation	IMP IMP: 通过突变表型推断	16116184	GOA
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	16116184	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: 通过直接分析推断	20209097	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: 通过直接分析推断	16116184	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: 通过突变表型推断	16116184	GOA
involved in positive regulation of interleukin-13 production	IDA IDA: 通过直接分析推断	20209097	GOA
involved in positive regulation of interleukin-4 production	IDA IDA: 通过直接分析推断	20209097	GOA
involved in positive regulation of interleukin-4 production	IMP IMP: 通过突变表型推断	25578313	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	24465902	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: 通过突变表型推断	24465902	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: 通过突变表型推断	24465902	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	25754930	GOA
involved in positive regulation of transforming growth factor beta production	IDA IDA: 通过直接分析推断	20209097	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: 通过直接分析推断	20209097	GOA
involved in positive regulation of type II interferon production	IDA IDA: 通过直接分析推断	20209097	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: 通过直接分析推断	21670307	GOA
NOT involved in regulation of interleukin-4 production	IDA IDA: 通过直接分析推断	16116184	GOA
NOT involved in regulation of interleukin-5 production	IDA IDA: 通过直接分析推断	16116184	GOA
NOT involved in regulation of p38MAPK cascade	IMP IMP: 通过突变表型推断	24465902	GOA
involved in response to interleukin-1	IDA IDA: 通过直接分析推断	23817958	GOA
involved in response to lipopolysaccharide	IMP IMP: 通过突变表型推断	25578313	GOA
NOT involved in toll-like receptor 2 signaling pathway	IDA IDA: 通过直接分析推断	16116184	GOA
NOT involved in toll-like receptor 4 signaling pathway	IDA IDA: 通过直接分析推断	16116184	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	23242525	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	20209097	GOA
located in nucleus	IDA IDA: 通过直接分析推断	23242525	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LGALS9 蛋白结构

Gal-bind_lectin

0
100
200
300
355 a.a.

蛋白主名

其他名称

galectin-9

ecalectin

重组 LGALS9 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70535	Galectin-9/LGALS9 Protein, Human (HEK293, His)	O00182-2 (M1-T323)	≥95%
HY-P70696	Galectin-9/LGALS9 Protein, Human (GST)	O00182-2 (M1-T323)	≥95%
HY-P75176	Galectin-9/LGALS9 Protein, Human (HEK293, hFc)	O00182-2 (A2-T323)	≥95%
HY-P700082AF	Animal-Free Galectin-9/LGALS9 Protein, Human (His)	O00182-2 (A2-T323)	≥95%

LGALS9 抗体

目录号	产品名	应用	反应物种
HY-P81382	Galectin 9 Antibody (YA1127)	IHC-P	Human

关联疾病

疾病名称

别名

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Patulous Eustachian Tube

Pet

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07610	LGALS9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07611	LGALS9B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	LGALS9	RGD	RGD:3005
Mus musculus	LGALS9	MGD	MGI:109496
Others	LGALS9	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LGALS9 - galectin 9 Gene

关于 LGALS9

功能概要

LGALS9 基因产物(3)

LGALS9 蛋白结构

重组 LGALS9 蛋白

LGALS9 抗体

关联疾病

直系同源

热门区域

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LGALS9 - galectin 9 Gene

关于 LGALS9

功能概要

LGALS9 基因产物(3)

LGALS9 蛋白结构

重组 LGALS9 蛋白

LGALS9 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z