2. Gene
  3. LTA4H - leukotriene A4 hydrolase Gene

LTA4H - leukotriene A4 hydrolase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白三烯 A4 水解酶

种属: Homo sapiens

基因 ID: 4048 | 基因类型: protein coding

关于 LTA4H

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,000,753-96,043,520 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 11 paralogues. Ubiquitous expression in lung (RPKM 63.8), bone marrow (RPKM 53.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种同时具有水解酶和氨肽酶活性的酶。水解酶活性用于促炎介质白三烯 B4 生物合成的最后一步。氨肽酶活性已显示可降解脯氨酸-甘氨酸-脯氨酸 (PGP) ，这是一种中性粒细胞趋化剂和慢性阻塞性肺病 (COPD) 的生物标志物。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is an Enzyme that contains both hydrolase and Aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The Aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

LTA4H 基因产物(7)

mRNA Protein Name
NM_000895.3 NP_000886.1 leukotriene A-4 hydrolase isoform 1
NM_001256643.1 NP_001243572.1 leukotriene A-4 hydrolase isoform 2
NM_001256644.1 NP_001243573.1 leukotriene A-4 hydrolase isoform 3
NM_001414263.1 NP_001401192.1 leukotriene A-4 hydrolase isoform 4
NM_001414264.1 NP_001401193.1 leukotriene A-4 hydrolase isoform 5
NM_001414265.1 NP_001401194.1 leukotriene A-4 hydrolase isoform 6
NM_001414266.1 NP_001401195.1 leukotriene A-4 hydrolase isoform 7

LTA4H 蛋白结构

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (19 - 387)

Leuk-A4-hydro_C

Leuk-A4-hydro_C: Leukotriene A4 hydrolase, C-terminal (464 - 608)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 611 a.a.
蛋白主名 其他名称

leukotriene A-4 hydrolase

LTA-4 hydrolase

重组 LTA4H 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70277 Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His) P09960-1 (M1-D611) ≥95%
HY-P73275 Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His) P09960-1/NP_000886.1 (M1-D611) ≥95%

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Soft Palate Cancer

Malignant Tumor Of Soft Palate

Malignant Tumor Of The Soft Palate

Palate Cancer Soft Palate
Lymph Node Tuberculosis

King'S Evil

Scrofula

Tuberculous Adenitis

Tuberculous Lymphadenopathy

Tuberculosis, Lymph Node
Psoriasis
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Leprosy 3

Leprosy

Leprosy, Susceptibility To, 3

Hansen'S Disease

Leprosy, Susceptibility To

Hansen Disease

Infection Due To Mycobacterium Leprae

LPRS3

Leprosy, Type 3

Anaesthesia Leprosy

Anaesthetic Leprosy

Maculoanaesthetic Leprosy

Macular Leprosy

Leprosy Unspecified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0494 Bufexamac Inhibitor ≥98.0% 否
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-137298 LTA4H-IN-1 Inhibitor 98.61% 否
HY-W027340 ARM1 Inhibitor 99.60% 否
HY-W004291 Methyl arachidate Inhibitor ≥98.0% 否
HY-10826 DG051 free acid Inhibitor / 否
HY-156960A JNJ-40929837 succinate Inhibitor / 否
HY-160646 LTA4H-IN-3 Inhibitor / 否
HY-161349 LTA4H-IN-4 Inhibitor / 否
HY-162710 LTA4H-IN-5 Inhibitor / 否
HY-N8760 Batatasin IV Inhibitor / 否
HY-RS07871 LTA4H Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W004291R Methyl arachidate (Standard) Inhibitor / 否
HY-156960 JNJ-40929837 Inhibitor / 否
HY-162015 LTA4H-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LTA4H VGNC VGNC:68100
Canis familiaris LTA4H VGNC VGNC:42853
Rattus norvegicus LTA4H RGD RGD:1311333
Macaca mulatta LTA4H VGNC VGNC:74453
Mus musculus LTA4H MGD MGI:96836
Bos taurus LTA4H VGNC VGNC:31067
Others LTA4H NCBI
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