LTA4H - leukotriene A4 hydrolase Gene

中文名称：白三烯 A4 水解酶

种属: Homo sapiens

基因 ID: 4048 | 基因类型: protein coding

关于 LTA4H

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,000,753-96,043,520 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 11 paralogues. Ubiquitous expression in lung (RPKM 63.8), bone marrow (RPKM 53.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种同时具有水解酶和氨肽酶活性的酶。水解酶活性用于促炎介质白三烯 B4 生物合成的最后一步。氨肽酶活性已显示可降解脯氨酸-甘氨酸-脯氨酸 (PGP) ，这是一种中性粒细胞趋化剂和慢性阻塞性肺病 (COPD) 的生物标志物。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is an Enzyme that contains both hydrolase and Aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The Aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

LTA4H 基因产物(7)

mRNA	Protein	Name
NM_000895.3	NP_000886.1	leukotriene A-4 hydrolase isoform 1
NM_001256643.1	NP_001243572.1	leukotriene A-4 hydrolase isoform 2
NM_001256644.1	NP_001243573.1	leukotriene A-4 hydrolase isoform 3
NM_001414263.1	NP_001401192.1	leukotriene A-4 hydrolase isoform 4
NM_001414264.1	NP_001401193.1	leukotriene A-4 hydrolase isoform 5
NM_001414265.1	NP_001401194.1	leukotriene A-4 hydrolase isoform 6
NM_001414266.1	NP_001401195.1	leukotriene A-4 hydrolase isoform 7

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables aminopeptidase activity	IDA IDA: 通过直接分析推断	9774412	GOA
enables epoxide hydrolase activity	IDA IDA: 通过直接分析推断	15078870	GOA
enables epoxide hydrolase activity	IMP IMP: 通过突变表型推断	11675384	GOA
enables leukotriene-A4 hydrolase activity	IDA IDA: 通过直接分析推断	9774412	GOA
enables metalloaminopeptidase activity	IMP IMP: 通过突变表型推断	11675384	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	15078870	GOA
enables zinc ion binding	IMP IMP: 通过突变表型推断	11675384	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in leukotriene biosynthetic process	IDA IDA: 通过直接分析推断	9774412	GOA
involved in leukotriene biosynthetic process	IMP IMP: 通过突变表型推断	11675384	GOA
involved in peptide catabolic process	IDA IDA: 通过直接分析推断	9774412	GOA
involved in protein metabolic process	IMP IMP: 通过突变表型推断	11675384	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LTA4H 蛋白结构

Peptidase_M1

Leuk-A4-hydro_C

0
100
200
300
400
500
611 a.a.

蛋白主名

其他名称

leukotriene A-4 hydrolase

LTA-4 hydrolase

LTA4H 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LTA4H	P09960	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
种属内	LTA4H	P09960	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LTA4H 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70277	Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His)	P09960-1 (M1-D611)	≥95%
HY-P73275	Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His)	P09960-1/NP_000886.1 (M1-D611)	≥95%

关联疾病

疾病名称

别名

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Lymph Node Tuberculosis

King'S Evil	Scrofula
Tuberculous Adenitis	Tuberculous Lymphadenopathy
Tuberculosis, Lymph Node

Psoriasis

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0494	Bufexamac	Inhibitor	≥98.0%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-137298	LYS006	Inhibitor	98.61%	否
HY-W027340	ARM1	Inhibitor	99.60%	否
HY-W004291	Methyl arachidate	Inhibitor	≥98.0%	否
HY-10826	DG051 free acid	Inhibitor	/	否
HY-156960A	JNJ-40929837 succinate	Inhibitor	/	否
HY-160646	LTA4H-IN-3	Inhibitor	/	否
HY-161349	LTA4H-IN-4	Inhibitor	/	否
HY-162710	LTA4H-IN-5	Inhibitor	/	否
HY-N8760	Batatasin IV	Inhibitor	/	否
HY-RS07871	LTA4H Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W004291R	Methyl arachidate (Standard)	Inhibitor	/	否
HY-156960	JNJ-40929837	Inhibitor	/	否
HY-162015	LTA4H-IN-2	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	LTA4H	VGNC	VGNC:68100
Canis familiaris	LTA4H	VGNC	VGNC:42853
Rattus norvegicus	LTA4H	RGD	RGD:1311333
Macaca mulatta	LTA4H	VGNC	VGNC:74453
Mus musculus	LTA4H	MGD	MGI:96836
Bos taurus	LTA4H	VGNC	VGNC:31067
Others	LTA4H	NCBI

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站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LTA4H - leukotriene A4 hydrolase Gene

关于 LTA4H

功能概要

LTA4H 基因产物(7)

LTA4H 蛋白结构

LTA4H 蛋白互作信息

重组 LTA4H 蛋白

关联疾病

直系同源

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LTA4H - leukotriene A4 hydrolase Gene

关于 LTA4H

功能概要

LTA4H 基因产物(7)

LTA4H 蛋白结构

LTA4H 蛋白互作信息

重组 LTA4H 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z