2. Gene
  3. CYP4F3 - cytochrome P450 family 4 subfamily F member 3 Gene

CYP4F3 - cytochrome P450 family 4 subfamily F member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞色素 P450 家族 4 亚家族 F 成员 3

种属: Homo sapiens

同用名: CPF3; CYP4F; LTB4H; CYPIVF3

基因 ID: 4051 | 基因类型: protein coding

关于 CYP4F3

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,640,897-15,662,825 (from NCBI)

This gene has 9 transcripts (splice variants), 364 orthologues and 12 paralogues. Biased expression in liver (RPKM 51.6), bone marrow (RPKM 29.9) and 6 other tissues.

功能概要

该基因 CYP4F3 编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。该蛋白质定位于内质网。该酶启动灭活和降解白三烯 B4 的过程，白三烯 B4 是一种有效的炎症介质。该基因是 19 号染色体上细胞色素 P450 基因簇的一部分。该家族的另一个成员 CYP4F8 距离大约 18 kb。已发现该基因编码两种不同亚型的几种转录变体。[RefSeq 提供，2019 年 4 月]

This gene, CYP4F3, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. This protein localizes to the endoplasmic reticulum. The Enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019]

CYP4F3 基因产物(4)

mRNA Protein Name
NM_000896.3 NP_000887.2 cytochrome P450 4F3 isoform a
NM_001199208.2 NP_001186137.1 cytochrome P450 4F3 isoform b
NM_001199209.2 NP_001186138.1 cytochrome P450 4F3 isoform b
NM_001369696.1 NP_001356625.1 cytochrome P450 4F3 isoform b

CYP4F3 蛋白结构

p450

p450: Cytochrome P450 (52 - 506)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
蛋白主名 其他名称

cytochrome P450 4F3

20-HETE synthase

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 6

IBD6
Trichuriasis

Whipworm Infection

Whipworm Disease

Trichocephaliasis

Infection By Trichuris Trichura

Trichuriasis Infection

Trichuris Trichiura Infection

Infection By Trichuris Trichiura

Trichocephalosis

Infection By Trichocephalus Trichiura

Infection By Trichuris

Infection By Trichuris Trichiuria

Trichuriosis

Whipworm

Infection Due To Trichuris Trichiura

Trichocephalus Infestation

Trichuris Infestation

Whipworm Infestation
Neuropathy, Hereditary Sensory And Autonomic, Type Ic

HSAN1C

Hsan Ic

Hsn1c

Hsn Ic

Hereditary Sensory And Autonomic Neuropathy Type 1c

Neuropathy, Hereditary Sensory And Autonomic, Type 1c

Neuropathy, Hereditary Sensory, Type Ic

Hereditary Sensory And Autonomic Neuropathy Type Ic

Neuropathy, Hereditary Sensory And Autonomic, 1c

Hereditary Sensory Neuropathy Type Ic

Neuropathy, Hereditary Sensory/Autonomic, Type Ic

Neuropathy, Sensory And Autonomic, Hereditary, Type Ic
Bietti Crystalline Corneoretinal Dystrophy

BCD

Bietti Crystalline Dystrophy

Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy

Bietti Crystalline Retinopathy

Bietti'S Crystalline Dystrophy

Crystalline Retinopathy

Dystrophy, Corneoretinal, Crystalline, Bietti
Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03482 CYP4F3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-113777 22-HDHA / 否
HY-121888 20-HEPE / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CYP4F3 RGD RGD:1305261
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