1. Gene
  2. MAP1A - microtubule associated protein 1A Gene

MAP1A - microtubule associated protein 1A Gene

中文名称:微管相关蛋白 1A

种属: Homo sapiens

同用名: MAP1L; MTAP1A

基因 ID: 4130 | 基因类型: protein coding

关于 MAP1A

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,510,954-43,531,611 (from NCBI)

This gene has 2 transcripts (splice variants), 266 orthologues and 2 paralogues. Biased expression in brain (RPKM 73.0), heart (RPKM 5.9) and 1 other tissue.

功能概要

该基因编码属于微管相关蛋白家族的蛋白质。该家族的蛋白质被认为参与微管组装,这是神经发生的重要步骤。该基因的产物是一种前体多肽,可能经过蛋白水解加工产生最终的 MAP1A 重链和 LC2 轻链。该基因的表达几乎完全在大脑中。对大鼠微管相关蛋白 1A 基因的研究表明它在脊髓发育的早期事件中起作用。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]

MAP1A 基因产物(2)

mRNA Protein Name
NM_001411089.1 NP_001398018.1 microtubule-associated protein 1A isoform 2
NM_002373.6 NP_002364.5 microtubule-associated protein 1A isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12812986 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

microtubule-associated protein 1A

MAP-1A

关联疾病

疾病名称 别名
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus MAP1A MGD MGI:1306776
Felis catus MAP1A VGNC VGNC:80917
Canis familiaris MAP1A VGNC VGNC:42955
Bos taurus MAP1A VGNC VGNC:31177
Rattus norvegicus MAP1A RGD RGD:3042
Macaca mulatta MAP1A VGNC VGNC:74489
Others MAP1A NCBI